Lithium visibility in rat brain and muscle in vivo by 7Li NMR imaging
Lithium visibility in rat brain and muscle in vivo by 7Li NMR imaging
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DOI：
10.1006/jmre.1998.1435
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发表时间：
1998-07-01
影响因子：
2.2
通讯作者：
Newton, JEO
中科院分区：
文献类型：
--
作者：
Komoroski, RA;Pearce, JM;Newton, JEO
通过在4.7 T下的Li-7 NMR成像，包括已知浓度和可见度的外标，测定了大鼠脑和肌肉中几个区域的锂（Li）的体内表观浓度。在所用给药条件下，肌肉的平均表观浓度为10.1 mM，不同脑区的平均表观浓度为4.2-5.3 mM。将结果与通过高分辨率Li-7 NMR光谱法从相同大鼠的脑和肌肉组织提取物在体外测定的浓度进行比较。该比较提供了每个组织区域中Li阳离子的Li-7 NMR可见性的估计。虽然在研究的五只大鼠中计算的维生素E存在相当大的分散，但结果表明，肌肉中的Li基本上完全可见（96%），而各个脑区的可见度有所降低（74-93%）。(C)北京：科学出版社.
The apparent concentration of lithium (Li) in vivo was determined for several regions in the brain and muscle of rats by Li-7 NMR imaging at 4.7 T with inclusion of an external standard of known concentration and visibility. The average apparent concentrations were 10.1 mM for muscle, and 4.2-5.3 mM for various brain regions under the dosing conditions used. The results were compared to concentrations determined in vitro by high-resolution Li-7 NMR spectroscopy of extracts of brain and muscle tissue from the same rats. The comparison provided estimates of the Li-7 NMR visibility of the Li cation in each tissue region. Although there was considerable scatter of the calculated visibilities among the five rats studied, the results suggested essentially full visibility (96%) for Li in muscle, and somewhat reduced visibility (74-93%) in the various brain regions. (C) 1998 Academic Press.