RELATIONSHIP OF EPITHELIAL OVARIAN-CANCER TO OTHER MALIGNANCIES WITHIN FAMILIES
RELATIONSHIP OF EPITHELIAL OVARIAN-CANCER TO OTHER MALIGNANCIES WITHIN FAMILIES
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DOI：
10.1002/gepi.1370050506
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发表时间：
1988-01-01
影响因子：
2.1
通讯作者：
THOMPSON, WD
中科院分区：
文献类型：
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作者：
SCHILDKRAUT, JM;THOMPSON, WD
在一项大型人群病例对照研究中，研究了乳腺癌、结肠/直肠癌、宫颈癌、子宫内膜癌、肺癌和甲状腺癌家族史与上皮性卵巢癌风险的关系。数据包括493例上皮性卵巢癌病例和2,465例年龄在20-54岁之间的对照组的家族史。在控制了潜在的混杂因素后，发现在一级亲属中报告乳腺癌和科洛/直肠癌的女性中，上皮性卵巢癌的风险显著升高。调整后的优势比分别为1.5（95% CI = 1.1-2.1）和1.9（95% CI = 1.1 - 2.1）。3.3）分别。其余四种癌症均未发现与上皮性卵巢癌的风险有统计学相关性。然而，当考虑上皮性卵巢癌的组织学亚型时，发现乳腺癌家族史与卵巢癌的风险升高相关（比值比= 2.3; 95%CI = 1.1-4.7），子宫内膜癌家族史也是如此（比值比= 2.7; 95%CI = 1.0-6.9）。这些结果被认为是在癌症的家族模式的其他研究的背景下，并与发表的关于在同一个人中发生多个原发性癌症的研究结果进行比较。研究结果表明，需要进一步研究上皮性卵巢癌和其他器官癌症之间可能的遗传关系。
The relationship of family history of cancer of the breast, colon/rectum, cervix, endometrium, lung, and thyroid to the risk of epithelial ovarian cancer was investigated in a large population-based case-control study. The data consisted of family histories from 493 epithelial ovarian cancer cases and 2,465 controls aged 20-54 years. After controlling for potential confounders, risk for epithelial ovarian cancer was found to be significantly elevated among women reporting breast cancer and colo/rectal cancer in a first-degree relative. Adjusted odds ratios were 1.5 (95% CI = 1.1-2.1) and 1.9 (95% CI = 1.1.-3.3), respectively. None of the remaining four types of cancer was found to be statistically associated with the risk of epithelial ovarian cancer. However, when histologic subtypes of epithelial ovarian cancer were considered, a family history of breast cancer was found to be associated with an elevated risk of endometrioid ovarian cancer (odds ratio = 2.3; 95% CI = 1.1-4.7), as was a family history of endometrial cancer (odds ratio= 2.7; 95% CI = 1.0-6.9). The results are considered in the context of other studies of familial patterns of cancer and are compared with published findings concerning the occurrence of multiple primary cancers in the same individual. The findings indicate that further study is warranted regarding possible genetic relationships between epithelial ovarian cancer and cancers arising in other organs.