Dynamic functional connectivity in Parkinson's disease patients with mild cognitive impairment and normal cognition
Dynamic functional connectivity in Parkinson's disease patients with mild cognitive impairment and normal cognition
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DOI：
10.1016/j.nicl.2017.12.013
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发表时间：
2018-01-01
影响因子：
4.2
通讯作者：
Ibarretxe-Bilbao, Naroa
中科院分区：
文献类型：
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作者：
Diez-Cirarda, Maria;Strafella, Antonio P.;Ibarretxe-Bilbao, Naroa
本研究旨在评估35例帕金森病（PD）伴轻度认知功能障碍（PD-MCI）和26例正常认知功能障碍（PD-NC）患者的动态功能连接（FC）和局部/整体连接。认知评估遵循广泛的神经心理电池。对于静息态功能MRI（rs-fMRI）分析，进行独立成分分析（ICA），成分位于7个网络中：皮层下（SC），听觉（AUD），躯体运动（SM），视觉（VI），认知控制（CC），默认模式（DMN）和小脑（CB）。使用GIFT工具箱进行动态FC分析。采用基于网络的统计（NBS）方法分析每个FC状态下组间的FC差异。最后，对局部/全局参数进行了图论分析，整个样本在rs-fMRI过程中表现出2种动态FC状态。与HC相比，PD-MCI患者在低连接状态下的平均停留时间缩短（p = 0.030），状态转换次数增加（p = 0.007）。此外，在低连通性状态下，PD-MCI患者与HC相比，SM-CC、SM-VI、SM-AUD、CC-VI和SC-DMN之间的网络间FC减少（p <0.05 FDR）。PD-MCI中的这些FC改变伴随着位于SM网络中的节点的图形拓扑改变（p <0.001）。相反，PD-NC和HC之间没有发现差异。研究结果表明，PD-MCI中存在PD-NC中不存在的动态功能性脑恶化，显示PD-MCI组动态FC功能障碍，主要在SM-CC网络和SM网络中的图形拓扑恶化之间减少FC。动态FC方法可能有助于理解PD的认知恶化。
The objective was to assess dynamic functional connectivity (FC) and local/global connectivity in Parkinson's disease (PD) patients with mild cognitive impairment (PD-MCI) and with normal cognition (PD-NC).The sample included 35 PD patients and 26 healthy controls (HC). Cognitive assessment followed an extensive neuropsychological battery. For resting-state functional MRI (rs-fMRI) analysis, independent component analysis (ICA) was performed and components were located in 7 networks: Subcortical (SC), Auditory (AUD), Somatomotor (SM), visual (VI), cognitive-control (CC), default-mode (DMN), and cerebellar (CB). Dynamic FC analysis was performed using the GIFT toolbox. FC differences between groups in each FC state were analysed with the network-based statistic (NBS) approach. Finally, a graph-theoretical analysis for local/global parameters was performed.The whole sample showed 2 dynamic FC states during the rs-fMRI. PD-MCI patients showed decreased mean dwell time in the hypo-connectivity state ( p = 0.030) and showed increased number of state transitions (p = 0.007) compared with the HC. In addition, in the hypo-connectivity state, PD-MCI patients showed reduced inter-network FC between the SM-CC, SM-VI, SM-AUD, CC-VI and SC-DMN compared with the HC ( p < 0.05FDR). These FC alterations in PD-MCI were accompanied by graph-topological alterations in nodes located in the SM network ( p < 0.001). In contrast, no differences were found between the PD-NC and HC.Findings suggest the presence of dynamic functional brain deteriorations in PD-MCI that are not present in PD-NC, showing the PD-MCI group dynamic FC dysfunctions, reduced FC mostly between SM-CC networks and graph-topological deteriorations in the SM network. A dynamic FC approach could be helpful to understand cognitive deterioration in PD.