The pedunculopontine tegmental nucleus and responding for sucrose reward
The pedunculopontine tegmental nucleus and responding for sucrose reward
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DOI：
10.1037/0735-7044.120.3.563
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发表时间：
2006-06-01
影响因子：
1.9
通讯作者：
Winn, Philip
中科院分区：
文献类型：
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作者：
Ainge, James A.;Keating, Glenda L.;Winn, Philip
啮齿类动物的脚桥被盖核（PPTg）病变导致蔗糖消耗增加，但这背后的心理缺陷仍然不确定。为了更好地理解蔗糖的消耗和动机之间的关系，作者训练大鼠穿过20%或4%蔗糖溶液的跑道; 7天后，浓度逆转。对照组大鼠消耗20%以上的4%蔗糖溶液，并迅速改变运行时间响应浓度变化。PPTg损伤大鼠消耗正常量的4%，但更多的20%蔗糖溶液比对照组，并需要更长的时间来改变他们的跑道时间后的浓度变化。这些数据表明，病变的PPTg不改变动机本身，可能会更好地理解为诱导反应选择缺陷。
Pedunculopontine tegmental nucleus (PPTg) lesions in rodents lead to increased sucrose consumption, but the psychological deficit behind this remains uncertain. To understand better the relationship between consumption of, and motivation for, sucrose, the authors trained rats to traverse a runway for 20% or 4% sucrose solution; after 7 days, concentrations were reversed. Control rats consumed more 20% than 4% sucrose solution and promptly altered run times in response to concentration change. PPTg-lesioned rats consumed normal quantities of 4% but more 20% sucrose solution than controls and took longer to alter their runway time following the concentration change. These data suggest that lesions of the PPTg do not alter motivation per se and might be better understood as inducing a response selection deficit.