The dual roles of A20 in cancer
The dual roles of A20 in cancer
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DOI：
10.1016/j.canlet.2021.04.017
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发表时间：
2021-05-03
期刊：
影响因子：
9.7
通讯作者：
Zhang, Lining
中科院分区：
文献类型：
--
作者：
Shi, Yongyu;Wang, Xinyu;Zhang, Lining
A20 是一种典型的抗炎分子，与包括癌症在内的多种人类疾病有关。 A20 作为肿瘤抑制因子的作用首先在 B 细胞淋巴瘤中被发现。随后的研究揭示了 A20 在实体癌中的双重作用。本综述重点关注 A20 在不同癌症类型中的作用，以证明 A20 的作用具有癌症类型依赖性。 A20 在结直肠癌和肝细胞癌中发挥抗肿瘤作用，而 A20 在乳腺癌、胃癌和黑色素瘤中充当癌基因。此外，A20 在神经胶质瘤治疗中的作用取决于具体情况。总结了A20在不同类型癌症中的作用机制。此外，还讨论了 A20 在抗肿瘤免疫中的作用。此外，还提出了这个快速发展的领域中的一些悬而未决的问题。探索 A20 在癌症中的作用和分子机制，为 A20 靶向方法在未来癌症治疗中的应用铺平了道路。
A20 is a prototypical anti-inflammatory molecule that is linked to multiple human diseases, including cancers. The role of A20 as a tumor suppressor was first discovered in B cell lymphomas. Subsequent studies revealed the dual roles of A20 in solid cancers. This review focuses on the roles of A20 in different cancer types to demonstrate that the effects of A20 are cancer type-dependent. A20 plays antitumor roles in colorectal carcinomas and hepatocellular carcinomas, whereas A20 acts as an oncogene in breast cancers, gastric cancers and melanomas. Moreover, the roles of A20 in the setting of glioma therapy are context-dependent. The action mechanisms of A20 in different types of cancer are summarized. Additionally, the role of A20 in antitumor immunity is discussed. Furthermore, some open questions in this rapidly advancing field are proposed. Exploration of the actions and molecular mechanisms of A20 in cancer paves the way for the application of A20-targeting approaches in future cancer therapy.