Mechanisms for motor timing in the cerebellar cortex.
Mechanisms for motor timing in the cerebellar cortex.
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DOI：
10.1016/j.cobeha.2016.01.013
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发表时间：
2016-04
影响因子：
5
通讯作者：
Medina JF
中科院分区：
文献类型：
--
作者：
Johansson F;Hesslow G;Medina JF
在经典的眨眼条件反射中，受试者学会对先前中性的刺激眨眼。这种条件性反应被定时为恰好在空气喷向眼睛之前发生。这种学习依赖于小脑皮层，在小脑皮层中，浦肯野细胞在自发放电中以适应性的定时暂停做出反应。抑制性浦肯野细胞的停顿引起小脑核的去抑制，从而引起明显的眨眼。浦肯野细胞反应的时间以前被认为需要输入信号中的时间代码，但最近的工作表明，浦肯野细胞可以通过代谢型谷氨酸受体（mGluR7）激活的内在机制来学习时间。
In classical eyeblink conditioning a subject learns to blink to a previously neutral stimulus. This conditional response is timed to occur just before an air puff to the eye. The learning is known to depend on the cerebellar cortex where Purkinje cells respond with adaptively timed pauses in their spontaneous firing. The pauses in the inhibitory Purkinje cells cause disinhibition of the cerebellar nuclei, which elicit the overt blinks. The timing of a Purkinje cell response was previously thought to require a temporal code in the input signal but recent work suggests that the Purkinje cells can learn to time their responses through an intrinsic mechanism that is activated by metabotropic glutamate receptors (mGluR7).