Design of novel biointerfaces (II). Fabrication of self-organized porous polymer film with highly uniform pores.
Design of novel biointerfaces (II). Fabrication of self-organized porous polymer film with highly uniform pores.
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发表时间：
2004
影响因子：
1
通讯作者：
Masaru Tanaka;Masafumi Takebayashi;Masashi Miyama;J. Nishida;M. Shimomura
中科院分区：
文献类型：
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作者：
Masaru Tanaka;Masafumi Takebayashi;Masashi Miyama;J. Nishida;M. Shimomura
多孔高分子材料在组织工程支架和人工器官（包括血液过滤器、透析器和氧合器膜）的新型生物界面中的应用已经取得进展。本研究描述了自组织高度规则的多孔聚合物膜的制备和表征，具有均匀的孔径大小通过简单的流延技术制备。研究了聚合物浓度、溶剂沸点、铸膜体积和基底等工艺参数对孔尺寸的影响。可以通过改变聚合物溶液的蒸发速率将孔径控制在1至50微米的范围内。孔径均匀的多孔膜用于组织工程支架和细胞分离膜。为了模拟从人血液中去除白细胞，将多孔膜连接到模块。具有5-9微米孔径的膜提供了从全血中分离白细胞的完全选择性。白细胞清除率取决于孔结构（大小和深度）以及血小板和红细胞的回收率。
Application of porous polymer materials to novel bio-interfaces for tissue engineering scaffold and artificial organs including blood filters, dialyzer, and oxygenator membranes have been in progress. The present study describes the fabrication and characterization of self-organized highly regular porous polymer films with uniform pore sizes are prepared by simple casting technique. Various fabrication parameters affecting the pore size such as polymer concentration, boiling point of solvent, cast volume and substrate are studied. The pore size can be controlled in the range from 1 to 50 microm by changing the evaporation rate of the polymer solutions. The porous film with uniform pore size is used for tissue engineering scaffold and cell separation membrane. To simulate the leukocyte eliminating from human blood, the porous film was attached to a module. The films with 5-9 microm pores provided the complete selectivity of separation for the leukocyte from the whole blood. The leukocyte elimination ratio depends on pore structures (size and depth) as well as recovery of platelet and erythrocyte.