Vasorelaxant properties of nicorandil on human radial artery.
Vasorelaxant properties of nicorandil on human radial artery.
复制标题
尼可地尔对人桡动脉的血管舒张特性。
DOI：
10.1016/s1010-7940(00)00325-0
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
D. Beech
中科院分区：
文献类型：
--
作者：
J. R. Sádaba;K. Mathew;C. Munsch;D. Beech
目的：桡动脉作为冠状动脉手术的通道越来越受欢迎，但其血管痉挛的倾向令人担忧。地尔硫卓在临床上用于预防血管痉挛，但有建议认为它相对无效。本研究的第一个目的是测试Ca 2+拮抗剂对血管收缩剂激动剂引起的血管痉挛的有效性。由于血管痉挛的大部分对钙拮抗剂有抵抗力，第二个目的是测试不同种类的血管扩张剂尼可地尔是否可以放松残余张力。方法：在接受心肌血管重建手术的患者中采集的人桡动脉段中记录等长张力。10 μM的地尔硫卓强烈抑制L型电压门控性Ca 2+通道，U46619（血栓素A2类似物）和内皮素-1（ET-1）引起的收缩舒张率分别为14.0±4.1%（n=10）和12.2±4.2%（n=10）。引人注目的是，尼可地尔放松了对地尔硫卓或尼卡地平抵抗的激动剂诱发的收缩。在不存在Ca 2+拮抗剂的情况下，尼可地尔（30 μM）诱发苯肾上腺素、U46619和内皮素-1诱发的收缩的74.1±5.6%（n=24）、36.8±9.3%（n=10）和64.5±7.9%（n=14）舒张。尼可地尔对三种不同的血管收缩剂激动剂诱发的收缩具有显著的舒张作用，并可缓解对传统Ca 2+拮抗剂耐药的血管痉挛。这些体外数据表明尼可地尔可能是心肌血运重建手术中抑制桡动脉血管痉挛的有用药物。
Objective: The radial artery is becoming popular as a conduit for coronary artery surgery but there is concern about its tendency to vasospasm. Diltiazem is used clinically in an effort to prevent vasospasm but there are suggestions that it is relatively ineffective. The first aim of the study was to test the effectiveness of Ca2+antagonists against vasospasm evoked by vasoconstrictor agonists. Because a large component of vasospasm was resistant to Ca2+antagonists, the second aim was to test if a different class of vasodilator, nicorandil, might relax the residual tone.Methods: Isometric tension was recorded in human radial artery segments harvested from patients undergoing myocardial revascularization surgery.Results: Diltiazem at 10 μM, which strongly inhibits L-type voltage-gated Ca2+channels, induced partial relaxation (mean±SEM, 44.6±3.5%, n=31) of phenylephrine-evoked contraction, but only 14.0±4.1% (n=10) and 12.2±4.2% (n=10) relaxation of U46619- (a thromboxane A2analogue) or endothelin-1-evoked contraction. Strikingly, nicorandil relaxed agonist-evoked contractions that were resistant to diltiazem or nicardipine. In the absence of a Ca2+antagonist, nicorandil (30 μM) evoked 74.1±5.6% (n=24), 36.8±9.3% (n=10) and 64.5±7.9% (n=14) relaxation of phenylephrine-, U46619- and endothelin-1-evoked contractions.Conclusions: Nicorandil has a marked relaxant effect on contractions evoked by three different vasoconstrictor agonists, and relaxes vasospasm that is resistant to conventional Ca2+antagonists. These in vitro data suggest that nicorandil might be a useful drug for the inhibition of radial artery vasospasm in myocardial revascularization surgery.