The road much traveled: trafficking in the cell nucleus
The road much traveled: trafficking in the cell nucleus
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DOI：
10.1016/j.ceb.2006.03.002
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发表时间：
2006-06-01
影响因子：
7.5
通讯作者：
Misteli, Tom
中科院分区：
文献类型：
--
作者：
Gorski, Stanislaw A.;Dundr, Miroslav;Misteli, Tom
RNA分子和蛋白质在细胞核内的运输是基因组功能的核心。最近的工作揭示了RNA和蛋白质在细胞核内和跨核膜运动的性质。这些研究深入了解了分子如何在核内找到它们的目的地，并揭示了核微环境的一些结构特性。RNA和蛋白质运输的控制现在正在成为基因表达和核功能的生理调节机制。
Trafficking of RNA molecules and proteins within the cell nucleus is central to genome function. Recent work has revealed the nature of RNA and protein motion within the nucleus and across the nuclear membrane. These studies have given insight into how molecules find their destinations within the nucleus and have uncovered some of the structural properties of the nuclear microenvironment. Control of RNA and protein trafficking is now emerging as a physiological regulatory mechanism in gene expression and nuclear function.