KINETICS OF POTASSIUM MOVEMENT IN NORMAL CORTEX
KINETICS OF POTASSIUM MOVEMENT IN NORMAL CORTEX
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DOI：
10.1016/0006-8993(76)90265-1
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发表时间：
1976-01-01
期刊：
影响因子：
2.9
通讯作者：
PRINCE, DA
中科院分区：
文献类型：
--
作者：
FISHER, RS;PEDLEY, TA;PRINCE, DA
在10只局部或巴比妥酸盐麻醉的猫的正常新皮质表面上灌注含有12 mEq/l钾（正常浓度的4倍）的人工CSF。测量细胞外钾浓度（[K+] 0 s）随时间（至8 h）和深度（至3 mm）的变化。分析[K+] 0 vs深度和[K+] 0 vs时间曲线表明，细胞外钾的分布可以通过扩散系数= 1.03 ± 0.16 sq.mm/h的扩散过程来模拟，以及扩散的表面屏障，其大小由屏障常数0.8 ± 0.2 mmm-1给出，并且对细胞和血管的主动摄取进行小的校正。获得的曲线与根据钾在水溶液中的动力学性质预测的曲线有很大不同。
Artificial CSF containing 12 mEq/1 of potassium (4 times normal concentration) was perfused over the surface of normal neocortex in 10 locally or barbiturate anesthetized cats. Extracellular potassium concentrations ([K+]0s) were measured as a function of time to 8 h and of depth to 3 mm. Analysis of the [K+]0versusdepth and [K+]0versustime profiles showed that the distribution of extracellular potassium could be modelled by a process of diffusion with diffusion coefficient = 1.03 ± 0.16 sq.mm/h, and a surface barrier to diffusion with magnitude given by a barrier constant 0.8 ± 0.2 mmm−1, and with a small correction for active uptake into cells and blood vessels. The profiles obtained differ considerably from those which could be predicted from kinetic properties of potassium in aqueous solution.