Diminished adult neurogenesis in the marmoset brain precedes old age
Diminished adult neurogenesis in the marmoset brain precedes old age
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DOI：
10.1073/pnas.0708228104
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发表时间：
2007-10-23
影响因子：
11.1
通讯作者：
Gould, Elizabeth
中科院分区：
文献类型：
--
作者：
Leuner, Benedetta;Kozorovitskiy, Yevgenia;Gould, Elizabeth
随着年龄的增长，海马齿状回新生成的神经元数量减少。在啮齿动物和树鼩中，这种与年龄相关的神经发生减少在动物变老之前就很明显了。以前没有研究调查过灵长类动物是否会随着年龄的增长而出现类似的海马神经发生下降。为了研究这种可能性，我们给年轻到中年的普通狨猴（Callithrix jacchus）注射了BrdU，并在3周后灌注。老年动物齿状回亚颗粒区/颗粒细胞层的新生细胞数量明显减少，且随年龄的增长呈线性减少。在脑室下区观察到类似的与年龄相关的新细胞减少，但在齿状回的门区没有观察到。这些数据表明，在成年狨猴的大脑中，神经发生的大量减少发生在衰老之前，这表明人类大脑中可能也会发生类似的变化。
With aging there is a decline in the number of newly generated neurons in the dentate gyrus of the hippocampus. In rodents and tree shrews, this age-related decrease in neurogenesis is evident long before the animals become aged. No previous studies have investigated whether primates exhibit a similar decline in hippocampal neurogenesis with aging. To investigate this possibility, young to middle aged adult common marmosets (Callithrix jacchus) were injected with BrdU and perfused 3 weeks later. The number of newly generated cells in the subgranular zone/granule cell layer of the dentate gyrus was significantly lower in older animals and decreased linearly with age. A similar age-related decline in new cells was observed in the subventricular zone but not in the hilar region of the dentate gyrus. These data demonstrate that a substantial decrease in neurogenesis occurs before the onset of old age in the adult marmoset brain, suggesting the possibility that similar alterations occur in the human brain.