Carbon nanotubes-based drug delivery to cancer and brain
Carbon nanotubes-based drug delivery to cancer and brain
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DOI：
10.1007/s11596-017-1783-z
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发表时间：
2017-10-01
影响因子：
--
通讯作者：
Xu, Shun-qing
中科院分区：
文献类型：
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作者：
Guo, Qing;Shen, Xian-tao;Xu, Shun-qing
目前对癌症和中枢神经系统疾病的治疗是有限的，部分原因是药物的不溶性、药物在细胞间的分布不佳、药物缺乏选择性、药物无法穿过细胞屏障和血脑屏障（BBB）所带来的困难。碳纳米管（CNTs）具有良好的电子特性、显著的细胞膜穿透能力、高载药和ph依赖的治疗卸载能力、热特性、大表面积和易于与分子修饰，这些特性使其成为向癌症和大脑输送药物的合适候选者。CNTs作为一种给药手段，可以达到高效、增强特异性和减少副作用的目的。虽然碳纳米管主要用于癌症治疗，但少数研究侧重于使用碳纳米管治疗和诊断中枢神经系统疾病。本文综述了国内外基于碳纳米管的肿瘤靶向给药系统（DDS）、光动力治疗（PDT）和光热治疗（PTT）的研究进展。同时，综述了碳纳米管脑内给药的国内外研究进展。
Current treatments for cancer and the central nervous system diseases are limited, partly due to the difficulties posed by the insolubility, poor distribution of drugs among cells and lack of selectivity of drugs, the inability of drugs to cross cellular barriers and blood brain barrier (BBB). Carbon nanotubes (CNTs) possess many distinct properties including good electronic properties, remarkably penetrating capability on the cell membrane, high drug-loading and pH-dependent therapeutic unloading capacities, thermal properties, large surface area and easy modification with molecules, which render them as a suitable candidate to deliver drugs to cancer and brain. CNTs as a drug delivery could achieve a high efficacy, enhance specificity and diminish side effects. Whereas CNTs have been primarily employed in cancer treatment, a few studies have focused on the treatment and diagnosis of the central nervous system diseases using CNTs. Here, we review the current progress of in vitro and in vivo researches of CNTs-based drug delivery to cancer involving CNTs-based tumor-targeted drug delivery systems (DDS), photodynamic therapy (PDT) and photothermal therapy (PTT). Meanwhile, we also review the current progress of in vitro and in vivo researches of CNTs-based drug delivery to brain.