The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
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DOI：
10.1016/j.immuni.2012.06.014
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发表时间：
2012-09-21
期刊：
影响因子：
32.4
通讯作者：
Hunter CA
中科院分区：
文献类型：
--
作者：
Hall AO;Beiting DP;Tato C;John B;Oldenhove G;Lombana CG;Pritchard GH;Silver JS;Bouladoux N;Stumhofer JS;Harris TH;Grainger J;Wojno ED;Wagage S;Roos DS;Scott P;Turka LA;Cherry S;Reiner SL;Cua D;Belkaid Y;Elloso MM;Hunter CA
干扰素-γ (IFN-γ)促进T-bet+ CXCR3+调节性T （Treg）细胞群，限制T辅助1 （Th1）细胞介导的病理。我们的研究表明，白细胞介素-27 （IL-27）也能促进Treg细胞中T-bet和CXCR3的表达。在弓形虫感染期间，出现了类似的群体，它们限制了T细胞的反应，并依赖于外周的IFN-γ，而依赖于粘膜部位的IL-27。在il - 27−/−小鼠中观察到，Treg细胞的转移改善了感染诱导的病理，这取决于它们产生IL-10的能力。微阵列分析显示，暴露于IFN-γ或IL-27的Treg细胞具有不同的转录谱。因此，IFN-γ和IL-27在Treg细胞生物学中具有不同的作用，IL-27是促进Treg细胞发育的关键细胞因子，专门控制局部炎症部位的Th1细胞介导的免疫。
Interferon-γ (IFN-γ) promotes a population of T-bet+ CXCR3+ regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii a similar population emerged which limited T cell responses and were dependent on IFN-γ in the periphery but IL-27 at mucosal sites. Transfer of Treg cells ameliorated the infection-induced pathology observed in Il27−/− mice and this was dependent on their ability to produce IL-10. Microarray analysis revealed that Treg cells exposed to either IFN-γ or IL-27 have distinct transcriptional profiles. Thus, IFN-γ and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation.
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DOI：
10.1084/jem.20100410
发表时间：
2011-01-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cox JH;Kljavin NM;Ramamoorthi N;Diehl L;Batten M;Ghilardi N
通讯作者：
Ghilardi N
DOI：
10.1084/jem.20101074
发表时间：
2010-10-25
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Grainger JR;Smith KA;Hewitson JP;McSorley HJ;Harcus Y;Filbey KJ;Finney CA;Greenwood EJ;Knox DP;Wilson MS;Belkaid Y;Rudensky AY;Maizels RM
通讯作者：
Maizels RM
DOI：
10.1084/jem.20021183
发表时间：
2002-11-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Aliberti J;Serhan C;Sher A
通讯作者：
Sher A
影响因子：
30.8
作者：
Imielinski, Marcin;Baldassano, Robert N.;Griffiths, Anne;Russell, Richard K.;Annese, Vito;Dubinsky, Marla;Kugathasan, Subra;Bradfield, Jonathan P.;Walters, Thomas D.;Sleiman, Patrick;Kim, Cecilia E.;Muise, Aleixo;Wang, Kai;Glessner, Joseph T.;Saeed, Shehzad;Zhang, Haitao;Frackelton, Edward C.;Hou, Cuiping;Flory, James H.;Otieno, George;Chiavacci, Rosetta M.;Grundmeier, Robert;Castro, Massimo;Latiano, Anna;Dallapiccola, Bruno;Stempak, Joanne;Abrams, Debra J.;Taylor, Kent;McGovern, Dermot;Heyman, Melvin B.;Ferry, George D.;Kirschner, Barbara;Lee, Jessica;Essers, Jonah;Grand, Richard;Stephens, Michael;Levine, Arie;Piccoli, David;Van Limbergen, Johan;Cucchiara, Salvatore;Monos, Dimitri S.;Guthery, Stephen L.;Denson, Lee;Wilson, David C.;Grant, Struan F. A.;Daly, Mark;Silverberg, Mark S.;Satsangi, Jack;Hakonarson, Hakon
通讯作者：
Hakonarson, Hakon
影响因子：
4.4
作者：
Esposito, Marianna;Ruffini, Francesca;Furlan, Roberto
通讯作者：
Furlan, Roberto