Heterozygous Avellino Corneal Dystrophy 9 Years After Photorefractive Keratectomy: Natural or Laser-induced Accelerated Course?
Heterozygous Avellino Corneal Dystrophy 9 Years After Photorefractive Keratectomy: Natural or Laser-induced Accelerated Course?
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DOI：
10.1097/ico.0b013e31818a7df7
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发表时间：
2009-05-01
期刊：
影响因子：
2.8
通讯作者：
Kim, Man Soo
中科院分区：
文献类型：
--
作者：
Park, Shin Hae;Mok, JeeWon;Kim, Man Soo
目的：报道一位屈光性角膜切除术（photorefractive keratectomy，PRK）治疗的患者，在手术后9年首次出现基质混浊，具有典型的颗粒状图案，经DNA分析证实为杂合子Avellino dystrophy.Methods：一位37岁的女性，17年前接受PRK，一直随访青光眼和角膜营养不良。结果：术后9年，29岁时，双眼首次检测到2-3个小的、白色的前基质角膜混浊。术后17年，在双眼中观察到相同程度的多个前基质角膜沉积物，具有斑点、碎屑或雪花外观。介入角膜相对清晰。她的DNA是杂合子的R124 H Mutation.Conclusions：缓慢发展，轻度皮质沉积后，heterozgote阿韦利诺角膜营养不良的患者，角膜移植。Avellino角膜营养不良患者在准分子激光屈光手术后会出现各种临床表现。
Purpose: To report a photorefractive keratectomy (PRK)-treated patient who first developed stromal opacities with a typical granular pattern 9 years after Surgery, which was confirmed as heterozygous Avellino dystrophy by DNA analysis.Methods: A 37-year-old woman, who had undergone PRK 17 years ago, has been followed for glaucoma and corneal dystrophy. She had preoperative clear corneas in both eyes.Results: Nine years after PRK, at the age of 29 years, 2-3 small, white, anterior stromal corneal opacities were first detected in both eyes. Seventeen years postoperatively, multiple anterior stromal corneal deposits with a dot, crumb, or snowflake appearance were noted to the same degree in both eyes. The intervening cornea was relatively clear. Her DNA was heterozygous for the R124H Mutation.Conclusions: Slowly developing, mild cortical deposits Occurred after PRK in this patient with heterozgote Avellino corneal dystrophy. Various clinical manifestations call occur after excimer laser refractive surgery in patients with Avellino corneal dystrophy.