Evaluation of Round Window Stimulation Performance in Otosclerosis Using Finite Element Modeling.
Evaluation of Round Window Stimulation Performance in Otosclerosis Using Finite Element Modeling.
复制标题
使用有限元模型评估耳硬化症的圆窗刺激性能
DOI：
10.1155/2016/3603207
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发表时间：
2016
影响因子：
--
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Yang S;Xu D;Liu X
圆窗（RW）刺激是一种新型的中耳植入物的应用，用于治疗中耳疾病，如耳硬化症。然而，临床结果显示出很大程度的可变性。变异性的一个来源是由疾病引起的耳部件的材料特性的变化。为了研究耳硬化症对RW刺激性能的影响，基于一组人颞骨的微型计算机断层扫描切片图像，建立了包括中耳和耳蜗的人耳有限元模型。在有限元模型中模拟了听觉系统中耳硬化症的三个特征性变化：镫骨环状韧带刚度增大、镫骨骨异常生长和锤骨部分固定。通过将模型预测结果与已发表的实验测量结果进行比较，验证了有限元模型。通过比较RW刺激与正常鼓膜声刺激产生的耳内压差，计算RW刺激的等效声压（ESP）。结果表明，镫骨环韧带的增加和锤骨的部分固定显著降低了低频RW刺激的ESP。相反，镫骨骨异常生长恶化RW刺激的ESP严重在较高的频率。
Round window (RW) stimulation is a new type of middle ear implant's application for treating patients with middle ear disease, such as otosclerosis. However, clinical outcomes show a substantial degree of variability. One source of variability is the variation in the material properties of the ear components caused by the disease. To investigate the influence of the otosclerosis on the performance of the RW stimulation, a human ear finite element model including middle ear and cochlea was established based on a set of microcomputerized tomography section images of a human temporal bone. Three characteristic changes of the otosclerosis in the auditory system were simulated in the FE model: stapedial annular ligament stiffness enlargement, stapedial abnormal bone growth, and partial fixation of the malleus. The FE model was verified by comparing the model-predicted results with published experimental measurements. The equivalent sound pressure (ESP) of RW stimulation was calculated via comparing the differential intracochlear pressure produced by the RW stimulation and the normal eardrum sound stimulation. The results show that the increase of stapedial annular ligament and partial fixation of the malleus decreases RW stimulation's ESP prominently at lower frequencies. In contrast, the stapedial abnormal bone growth deteriorates RW stimulation's ESP severely at higher frequencies.