Worldwide burden of cervical cancer in 2008
Worldwide burden of cervical cancer in 2008
复制标题
DOI：
10.1093/annonc/mdr015
复制
发表时间：
2011-12-01
影响因子：
50.5
通讯作者：
Ferlay, J.
中科院分区：
文献类型：
--
作者：
Arbyn, M.;Castellsague, X.;Ferlay, J.
背景：认识到持续的人乳头瘤病毒感染是宫颈癌的主要原因，导致了检测病毒核酸和预防性疫苗的试验的发展。需要最新和可靠的数据来评估现有预防措施的影响和确定今后的优先事项。材料和方法：根据最近汇编的2008年癌症和死亡率登记处的数据，给出了宫颈癌发病率和死亡率的最佳估计。结果：2008年估计有53万宗子宫颈癌个案，并有275 000人死于子宫颈癌。它是继乳腺癌（138万例）和结直肠癌（57万例）之后的第三大常见女性癌症。子宫颈癌的发病率在各国之间差别很大，世界年龄标准化发病率从每10万人1至50人不等。子宫颈癌是东非、西非和中非妇女癌症相关死亡的主要原因；中美洲;中南亚和美拉尼西亚。几内亚的发病率最高，在75岁之前患宫颈癌的妇女约占6.5%。印度是发病频率最高的国家，有13.4万例病例和7.3万例死亡。宫颈癌比其他主要癌症更容易影响45岁以下的妇女。结论：尽管有有效的筛查方法，子宫颈癌仍然是一个主要的公共卫生问题。应通过组织良好的方案向所有国家的妇女提供和利用预防宫颈癌的新方法。
Background: The knowledge that persistent human papillomavirus infection is the main cause of cervical cancer has resulted in the development of assays that detect nucleic acids of the virus and prophylactic vaccines. Up-to-date and reliable data are needed to assess impact of existing preventive measures and to define priorities for the future.Materials and methods: Best estimates on cervical cancer incidence and mortality are presented using recently compiled data from cancer and mortality registries for the year 2008.Results: There were an estimated 530 000 cases of cervical cancer and 275 000 deaths from the disease in 2008. It is the third most common female cancer ranking after breast (1.38 million cases) and colorectal cancer (0.57 million cases). The incidence of cervical cancer varies widely among countries with world age-standardised rates ranging from < 1 to > 50 per 100 000. Cervical cancer is the leading cause of cancer-related death among women in Eastern, Western and Middle Africa; Central America; South-Central Asia and Melanesia. The highest incidence rate is observed in Guinea, with similar to 6.5% of women developing cervical cancer before the age of 75 years. India is the country with the highest disease frequency with 134 000 cases and 73 000 deaths. Cervical cancer, more than the other major cancers, affects women < 45 years.Conclusions: In spite of effective screening methods, cervical cancer continues to be a major public health problem. New methodologies of cervical cancer prevention should be made available and accessible for women of all countries through well-organised programmes.