Exposure to a dry environment enhances epidermal permeability barrier function
Exposure to a dry environment enhances epidermal permeability barrier function
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DOI：
10.1046/j.1523-1747.1998.00333.x
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发表时间：
1998-11-01
影响因子：
6.5
通讯作者：
Feingold, KR
中科院分区：
文献类型：
--
作者：
Denda, M;Sato, J;Feingold, KR
以往的研究表明，经表皮水分运动可能在表皮稳态和屏障修复中发挥重要作用。在这里，我们分析了皮肤屏障功能，表皮形态，角质层的脂质含量在无毛小鼠保持在高相对湿度（RH > 80%）与低湿度（RH < 10%）的环境中2周。基底经表皮水分流失减少了31%的动物保持在干燥的Venus潮湿的环境。此外，在保持在干燥环境中的动物中，颗粒层细胞中的板层体的数量、板层体胞吐的程度和角质层的层数增加。此外，角质层的干重和表皮的厚度也在干燥环境中增加。此外，总角质层脂质增加，但脂质分析显示脂质分布无显著差异。最后，在丙酮处理或胶带剥离后的屏障恢复在长时间暴露于干燥环境后加速，而相反地，在暴露于潮湿环境后延迟。这些研究表明，环境条件显着影响表皮结构和功能，并提出了环境可能诱发或加剧各种皮肤疾病的机制。
Previous studies have suggested that transepidermal water movement may play an important role in epidermal homeostasis and barrier repair. Here we analyzed cutaneous barrier function, epidermal morphology, and lipid content of the stratum corneum in hairless mice maintained in a high relative humidity (RH > 80%) versus low humidity (RH < 10%) environment for 2 wk. Basal transepidermal water loss was reduced by 31% in animals maintained in a dry venus humid environment. Moreover, the number of lamellar bodies in stratum granulosum cells, the extent of lamellar body exocytosis, and the number of layers of stratum corneum increased in animals kept in a dry environment. Furthermore, the dry weight of the stratum corneum and the thickness of the epidermis also increased in a dry environment. in addition, total stratum corneum lipids increased but lipid analysis revealed no significant differences in lipid distribution. Lastly, barrier recovery following either acetone treatment Or tape stripping was accelerated after prolonged prior exposure to a dry environment, while conversely, it was delayed by prior exposure to a humid environment. These studies demonstrate that environmental conditions markedly influence epidermal structure and function, and suggest mechanisms by which the environment could induce or exacerbate various cutaneous disorders.