Conditioning of ictal and interictal behaviors in rats by amygdala kindling: context as the conditional stimulus.
Conditioning of ictal and interictal behaviors in rats by amygdala kindling: context as the conditional stimulus.
复制标题
通过杏仁核点燃调节大鼠的发作和发作间期行为：上下文作为条件刺激。
作者：
S. Barnes;J. Pinel;L. Francis;G. Wig
结果表明，刺激环境的条件效应可以调节杏仁核点燃大鼠的临界和间歇行为。大鼠在1种条件刺激（CS+）情境下接受53次左基底外侧杏仁核刺激，在另一种情境（CS-）下接受53次假刺激（连接刺激导联但不传递电流），准随机持续54天。观察到三种条件效应。首先，经过几次刺激后，与CS-情境相比，CS+情境的运动活动更少，冻结更多，饲养更少。其次，经过45次刺激后，所有大鼠在条件位置偏好测试中都选择了CS-情境而不是CS+情境。第三，当大鼠最终在CS环境下受到刺激时，它们的运动癫痫发作不那么严重：潜伏期更长，运动癫痫发作时间更短，抽搐模式更低，摔倒次数更少。
The authors showed that conditional effects of the stimulation environment modulate both the ictal and interictal behaviors of rats subjected to amygdala kindling. Rats received 53 stimulations to the left basolateral amygdala in 1 conditional stimulus (CS) context (CS+) and 53 sham stimulations (the stimulation lead was attached but no current was delivered) in another context (CS-), quasirandomly over 54 days. Three kinds of conditional effects were observed. First, after several stimulations, less ambulatory activity, more freezing, and less rearing reliably occurred in the CS+ context than in the CS-context. Second, after 45 stimulations, all of the rats chose the CS- context over the CS+ context in a conditioned place preference test. Third, when the rats were finally stimulated in the CS- context, their motor seizures were less severe: Latencies were longer, motor seizures were shorter, convulsive patterns were of a lower class, and there were fewer falls.