An evaluation of cardiopulmonary endurance and muscular strength in adults living with sickle cell disease.
An evaluation of cardiopulmonary endurance and muscular strength in adults living with sickle cell disease.
复制标题
镰状细胞病成人心肺耐力和肌肉力量的评估。
DOI：
10.1111/bjh.18436
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发表时间：
2022
影响因子：
6.5
通讯作者：
Lanzkron,SophieM
中科院分区：
文献类型：
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作者：
Ogunsile,FolusoJ;Stewart,KerryJ;Kanter,Julie;Lanzkron,SophieM
对镰状细胞病（SCD）的运动研究有限。在一般人群中，健康反映在一般的身体素质。目前还不清楚是否在SCD患者中也发现了同样的关联。在这里，我们报告了一个横断面评估的两个重要措施的身体健康，肌肉力量和心肺耐力，在成人SCD。共有29名成年SCD患者（年龄24-62岁; 72%为女性）使用自行车测力计和等速测力计完成心肺和肌肉力量测试。成人SCD患者的心肺耐力中位数较低（中位数[四分位距，IQR]峰值摄氧量[VO 2] 16.1 [6.3] vs. 42.65 [11.3] ml/kg/min，p< 0.001）和膝关节强度（中位数[IQR]屈肌扭矩26.91[22.5] vs. 55.6 [22.7] Nm，p< 0.001）。有趣的是，成人SCD患者的肌力和峰值VO 2值之间存在非常正相关（r= 0.53，p = 0.003），提示这些值可能有助于确定心肺健康状况。
There have been limited investigations into exercise in sickle cell disease (SCD). In the general population, health is reflected in general physical fitness. It is unclear if the same associations are seen in people with SCD. Here, we report a cross‐sectional assessment of two important measures of physical fitness, muscle strength and cardiorespiratory endurance, in adults with SCD. A total of 29 adults with SCD (aged 24–62 years; 72% female) completed cardiopulmonary and muscular strength testing using a cycle ergometer and an isokinetic dynamometer. Adults with SCD had lower median values for cardiorespiratory endurance (the median [interquartile range, IQR] peak oxygen uptake [VO2] 16.1 [6.3] vs. 42.65 [11.3] ml/kg/min,p< 0.001) and knee strength (median [IQR] flexor torque 26.91[22.5] vs. 55.6 [22.7] Nm,p< 0.001) compared to controls and predicted values. Interestingly, there was a very positive association between muscular strength and peak VO2values for adults with SCD (r= 0.53,p= 0.003) suggesting these values may be useful in determining cardiopulmonary health.