Different populations of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) from Central Africa are susceptible to Zika virus infection
Different populations of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) from Central Africa are susceptible to Zika virus infection
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DOI：
10.1371/journal.pntd.0008163
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发表时间：
2020-03-01
影响因子：
3.8
通讯作者：
Failloux, Anna-Bella
中科院分区：
文献类型：
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作者：
Kamgang, Basile;Vazeille, Marie;Failloux, Anna-Bella
寨卡病毒（ZIKV）于1947年在乌干达首次分离出来，主要通过属于伊蚊属的受感染蚊子的叮咬传播给人类，特别是Ae。埃及伊蚊和埃及伊蚊。白纹伊蚊这两种伊蚊都存在于中非，但它们在流行病学中的作用特征不明显。在这里，我们评估了Ae的能力。埃及伊蚊和埃及伊蚊。在中非的不同生态环境中收集的白纹伊蚊传播在西非分离的ZIKV毒株。分析表明，Ae.埃及伊蚊和埃及伊蚊。白纹伊蚊能够传播ZIKV，但Ae的总传播效率更高。Aegypti与Ae相比。白纹伊蚊此外，两种伊蚊的传播感染率和传播率因采样地点而异。总的来说，我们的结果表明，在中非，Ae。埃及伊蚊比埃及伊蚊更有能力传播ZIKV。白纹伊蚊虽然进食行为、寿命和蚊子密度等参数可调节病原体在自然界的传播。寨卡病毒（Zika virus，ZIKV）是一种黄病毒属（Flaviviridae）病毒，主要通过被感染的伊蚊叮咬传播给人类。埃及伊蚊是ZIKV和Ae的主要流行媒介。白纹伊蚊是第二种然而，这两种伊蚊在中非的流行病学作用，其中Ae。最近引进的白纹伊蚊的特征很差。现场采集的Ae.埃及伊蚊和埃及伊蚊。来自中非不同生态环境的白纹伊蚊实验性感染西非分离的ZIKV毒株。在接触后14天和21天对蚊子进行了分析。两个Ae。埃及伊蚊和埃及伊蚊。白纹伊蚊能够传播ZIKV，但Ae的总体传播效率更高。埃及伊蚊（57.9%），而Ae.白纹伊蚊占41.5%。此外，传播感染和传播率为两个AE。埃及伊蚊和埃及伊蚊。白纹伊蚊的数量因采样地点不同而有显著差异。我们得出的结论是，两者都是Ae.埃及伊蚊和埃及伊蚊。白纹伊蚊能够传播寨卡病毒，并可能作为活跃的寨卡病毒载体在中非进行干预。这些发现有助于更好地了解ZIKV在中部非洲的流行病学传播，并制定适当的策略来预防该地区的重大ZIKV疫情。
Author summaryZika virus (ZIKV), isolated for the first time in Uganda in 1947, is transmitted to human beings mainly by the bite of an infected mosquitoes belonging to the Aedes genus notably Ae. aegypti and Ae. albopictus. Both Aedes species are present in Central Africa, however their epidemiological role is poorly characterized. Here, we assessed the ability of Ae. aegypti and Ae. albopictus collected in different ecological settings in Central Africa to transmit a ZIKV strain isolated in West Africa. Analysis showed that both Ae. aegypti and Ae. albopictus are able to transmit ZIKV but with higher overall transmission efficiency for Ae. aegypti compared to Ae. albopictus. In addition, disseminated infection and transmission rates for both Aedes species varied significantly according to the sampling location. Overall, our result suggests that in Central Africa, Ae. aegypti is more competent to transmit ZIKV than Ae. albopictus although parameters such as the feeding behaviour, longevity and mosquito densities can modulate pathogens transmission in nature. These findings could contribute to a better understanding of the epidemiological transmission of ZIKV in Central Africa and develop suitable strategy to prevent major ZIKV outbreaks in this region.Zika virus (ZIKV) is a Flavivirus (Flaviviridae) transmitted to humans mainly by the bite of an infected Aedes mosquitoes. Aedes aegypti is the primary epidemic vector of ZIKV and Ae. albopictus, the secondary one. However, the epidemiological role of both Aedes species in Central Africa where Ae. albopictus was recently introduced is poorly characterized. Field-collected strains of Ae. aegypti and Ae. albopictus from different ecological settings in Central Africa were experimentally infected with a ZIKV strain isolated in West Africa. Mosquitoes were analysed at 14- and 21-days post-exposure. Both Ae. aegypti and Ae. albopictus were able to transmit ZIKV but with higher overall transmission efficiency for Ae. aegypti (57.9%) compared to Ae. albopictus (41.5%). In addition, disseminated infection and transmission rates for both Ae. aegypti and Ae. albopictus varied significantly according to the location where they were sampled from. We conclude that both Ae. aegypti and Ae. albopictus are able to transmit ZIKV and may intervene as active Zika vectors in Central Africa. These findings could contribute to a better understanding of the epidemiological transmission of ZIKV in Central Africa and develop suitable strategy to prevent major ZIKV outbreaks in this region.