Method for regio-, chemo- and stereoselective deuterium labeling of sugars based on ruthenium-catalyzed C-H bond activation
Method for regio-, chemo- and stereoselective deuterium labeling of sugars based on ruthenium-catalyzed C-H bond activation
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DOI：
10.1039/c0cc01197e
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Sajiki, Hironao
中科院分区：
文献类型：
--
作者：
Fujiwara, Yuta;Iwata, Hiroki;Sajiki, Hironao
使用 Ru/C-H(2)-D(2)O 组合，通过 Ru 与糖羟基氧原子的配位辅助的 C-H 键活化，以完全区域选择性、化学选择性和立体选择性方式实现了高效、简便的糖氘标记。
An efficient and facile deuterium labeling of sugars has been achieved in a completely regio-, chemo- and stereoselective manner using the Ru/C-H(2)-D(2)O combination via C-H bond activation assisted by the coordination of Ru to the oxygen atom of the sugar-hydroxyl groups.