Changes of peripheral lymphocyte subset in patients with SARS-CoV-2 infection during the whole course of disease
Changes of peripheral lymphocyte subset in patients with SARS-CoV-2 infection during the whole course of disease
复制标题
DOI：
10.1080/17476348.2021.1866991
复制
发表时间：
2020-12
影响因子：
3.9
通讯作者：
Xingxia Yu;R. Yang
中科院分区：
文献类型：
--
作者：
Xingxia Yu;R. Yang
摘要背景：SARS-CoV-2感染后淋巴细胞亚群的变化尚不清楚。方法：对武汉大学中南医院2019年12月20日至2020年3月8日收治的580例新冠肺炎患者的临床资料进行回顾性分析。分析淋巴细胞亚群与病情严重程度及预后的关系。结果：发病后2~3周，淋巴细胞亚群降至最低水平。除CD8+T细胞外，无症状患者的淋巴细胞亚群水平与正常人接近。重症患者的淋巴细胞亚群水平低于轻中度患者(P5000拷贝/ml和500-5000拷贝/ml)。结论：淋巴细胞亚群是一个很好的生物标志物，可以在症状出现后2-3周评估疾病的严重程度和预后。
ABSTRACT Background: Little is known about changes in lymphocyte subsets after SARS-CoV-2 infection. Methods: Clinical data of 580 COVID-19 patients hospitalized in Zhongnan Hospital of Wuhan University from 20 December 2019, to 8 March 2020, were retrospectively analyzed. The relation of lymphocyte subsets and severity or prognosis of disease were analyzed. Results: At 2–3 weeks after the onset of symptoms, lymphocyte subsets decreased to the lowest levels. The levels of lymphocyte subsets in asymptomatic patients were close to healthy persons, except for CD8+ T lymphocyte cells. The levels of lymphocyte subsets in patients with severe illness were lower than that in patients with mild-to-moderate illness (P 5000 copies/ml and 500–5000 copies/ml were at similar levels. Conclusions: Lymphocyte subsets are a good biomarker to assess the severity and prognosis of the disease at 2–3 weeks after the onset of symptoms.