The influence of the subsurface cisterna on the electrical properties of the outer hair cell
The influence of the subsurface cisterna on the electrical properties of the outer hair cell
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DOI：
10.1097/00001756-199707280-00020
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发表时间：
1997-07-28
期刊：
影响因子：
1.7
通讯作者：
Brownell, WE
中科院分区：
文献类型：
--
作者：
Halter, JA;Kruger, RP;Brownell, WE
外毛细胞的分布参数计算模型被用来预测从电流注入所产生的电位。发现与长度依赖性全细胞电导和电容的良好拟合。该拟合要求存在亚表面池和侧壁质膜的低（0.001 mS/cm（2））比电导率。外侧壁不能被空间夹持，因为显著的纵向电流通过脑池外空间而不是轴向核心。脑池外间隙宽度的减小降低了全细胞电导和电容。位置相关的相移，注意到在注射过程中的正弦电流（0.001575拉德/亩）。这些预测支持在实验观察到的非线性电容和电动性的作用，脑池外纵向电位梯度。
A distributed-parameter computational model of the outer hair cell was used to predict the potentials resulting from current injection. A good fit was found to the length-dependent whole cell conductance and capacitance. The fit required the presence of the subsurface cisterna and a low (0.001 mS/cm(2)) specific conductivity for the plasma membrane of the lateral wall. The lateral wall could not be space clamped as significant longitudinal currents pass through the extracisternal space vs the axial core. A reduction in the width of the extracisternal space decreased the whole-cell conductance and capacitance. Position-dependent phase shifts were noted during injection of sinusoidal currents (0.001575 rad/mu). These predictions support a role for extracisternal longitudinal potential gradients in experimentally observed non-linear capacitance and electromotility.