Lipogenic metabolism: a viable target for prostate cancer treatment?
Lipogenic metabolism: a viable target for prostate cancer treatment?
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DOI：
10.4103/1008-682x.132947
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发表时间：
2014-09
影响因子：
2.9
通讯作者：
Mulholland DJ
中科院分区：
文献类型：
--
作者：
Liang M;Mulholland DJ
与正常细胞相比，癌细胞通常依赖于改变的代谢。正如奥托瓦尔堡在1924年所观察到的，癌细胞通过有氧糖酵解显示出优先的葡萄糖消耗，而正常细胞通常呈现线粒体氧化磷酸化。癌发生的另一个代谢标志是脂质代谢改变，由此癌细胞可以采用增强的从头脂质产生（脂肪生成）。在患有代谢综合征的个体中也观察到脂质代谢增强，这可能是由高水平的饱和脂肪和碳水化合物组成的标准美国饮食越来越受欢迎的结果。越来越多的流行病学数据表明，代谢综合征，如心血管疾病、肥胖症、2型糖尿病和相关的高胰岛素血症的发生与癌症的侵袭性之间存在正相关。值得注意的是，据估计，饱和脂肪每减少1%，被多不饱和脂肪取代，心血管疾病就会减少2%-3%。因此，可以想象的是，随着脂质积累的这种减少，癌症进展的同样显著的减弱可能会实现。
Cancer cells often depend on altered metabolism compared with their normal counterparts. As observed in 1924 by Otto Warburg, cancer cells show preferential glucose consumption by way of aerobic glycolysis while normal cells generally assume mitochondrial oxidative phosphorylation. Another metabolic hallmark of carcinogenesis is altered lipid metabolism, whereby cancer cells may adopt enhanced de novo lipid production (lipogenesis). Enhanced lipid metabolism is also observed in individuals with metabolic syndromes potentially a consequence of increasing popularity of the Standard American Diet, composed of high levels of saturated fats and carbohydrates. A growing body of epidemiological data indicates a positive correlation between the occurrence of metabolic syndromes, such as cardiovascular disease, obesity, type-2 diabetes and associated hyperinsulemia, with the aggressiveness of cancer. Remarkably, it is estimated that for every 1% reduction in saturated fats, replaced by polyunsaturated, there would be a 2%–3% reduction in cardiovascular disease. Thus, it is conceivable that an equally remarkable attenuation in cancer progression might be achieved with such a reduction in lipid accumulation.