Association between serum levels of n-3 polyunsaturated fatty acids and coronary plaque detected by coronary computed tomography angiography in patients receiving statin therapy.
Association between serum levels of n-3 polyunsaturated fatty acids and coronary plaque detected by coronary computed tomography angiography in patients receiving statin therapy.
复制标题
在接受他汀类药物治疗的患者中，n-3 多不饱和脂肪酸的血清水平与通过冠状动脉计算机断层扫描血管造影检测到的冠状动脉斑块之间的关联。
DOI：
10.1253/circj.cj-13-0257
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Y. Kihara
中科院分区：
文献类型：
--
作者：
Y. Urabe;Hideya Yamamoto;T. Kitagawa;Hiroto Utsunomiya;H. Tsushima;F. Tatsugami;K. Awai;Y. Kihara
背景
他汀类药物强化降脂治疗可减少心血管事件，但残留的心血管风险仍然存在。 n-3 多不饱和脂肪酸 (PUFA) 的摄入与心血管事件有关。我们研究了接受他汀类药物治疗的患者血清 n-3 PUFA 与计算机断层扫描血管造影 (CTA) 冠状动脉粥样硬化结果之间的关系。
方法和结果
我们招募了 172 名受试者（平均年龄：68.2 岁；64% 为男性），接受他汀类药物治疗 6 个月。测量了血清 PUFA，包括二十碳五烯酸 (EPA)、二十二碳六烯酸 (DHA) 和花生四烯酸。当根据中位EPA水平（61.3 μg/ml）将患者分为2组时，低EPA组显示3支血管斑块受累的发生率较高（62% vs. 43%，P=0.015）、非钙化斑块（NCP）（74% vs. 52%，P=0.0016）、广泛NCP（≥2节段）（56% vs. 34%， P=0.0036）和高风险斑块（最小 CT 密度 <39 HU 且重塑指数 >1.05）（43% vs. 22%，P=0.0034）。多变量分析显示，低 EPA 水平是这些冠状动脉斑块发现的独立因素。 DHA 水平与这些发现并不独立相关。
结论
在接受他汀类药物降脂治疗的患者中，低血清 EPA 水平（而非血清 DHA）与冠状动脉 CTA 检测到的 NCP 和高风险斑块的存在和程度相关。
BACKGROUND
Intensive lipid-lowering therapy with statins reduces cardiovascular events, but residual cardiovascular risks remain. Intake of n-3 polyunsaturated fatty acids (PUFAs) has been associated with cardiovascular events. We examined the relationships between serum n-3 PUFAs and coronary atherosclerotic findings on computed tomography angiography (CTA) in patients undergoing statin treatment.
METHODS AND RESULTS
We enrolled 172 subjects (mean age: 68.2 years; 64% men) prior to statin treatment for 6 months. Serum PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid, were measured. When the patients were divided into 2 groups according to the median EPA level (61.3 μg/ml), the low-EPA group showed higher incidences of 3-vessel plaque involvement (62% vs. 43%, P=0.015), noncalcified plaques (NCPs) (74% vs. 52%, P=0.0016), extensive NCPs (≥ 2 segments) (56% vs. 34%, P=0.0036), and high-risk plaques (minimum CT density <39 HU and remodeling index >1.05) (43% vs. 22%, P=0.0034). Multivariate analyses revealed that low EPA levels were an independent factor for these coronary plaque findings. The DHA levels were not independently associated with these findings.
CONCLUSIONS
Low serum EPA level, but not serum DHA, is associated with the presence and extent of NCPs and high-risk plaques detected by coronary CTA in patients undergoing lipid-lowering therapy with statins.
影响因子：
4.2
作者：
Mozaffarian, Dariush;Wu, Jason H. Y.
通讯作者：
Wu, Jason H. Y.