Fat Intake and CNS Functioning: Ageing and Disease
Fat Intake and CNS Functioning: Ageing and Disease
复制标题
DOI：
10.1159/000229003
复制
发表时间：
2009-01-01
影响因子：
3.9
通讯作者：
Sinclair, Andrew J.
中科院分区：
文献类型：
--
作者：
Crawford, Michael A.;Bazinet, Richard P.;Sinclair, Andrew J.
1972年，Crawford和Sinclair发表了AA和DHA是大脑生长和进化的独立决定因素的证据[Crawford和Sinclair 1972; Broadhurst等人，2002; Enard等人，2002; Pennisi 2002]。啮齿类动物缺乏症研究[Sinclair和Crawford 1972; Benolken等人，1973; Galli和Socini，1983; Weisinger等人，1999; Catalan等人，2002]、鸡[Budowski等人，1987]，灵长类动物[Fiennes等人，1973; Neuringer等人，1986]，以及人类婴儿的视觉和认知试验[Carlson和Werkman，1996; Martinez和Vazquez，1998; Birch等人，2000]已经表明AA和DHA对于大脑发育和功能都是必不可少的。此外，n-6/n-3脂肪酸之间存在的竞争适用于它们的平衡，这对大脑发育和结构完整性至关重要[Budowski和Crawford，1985]。DHA对视力、脑神经元和细胞信号传导至关重要。
In 1972, Crawford and Sinclair published evidence that AA and DHA were independent determinants of brain growth and evolution [Crawford and Sinclair 1972; Broadhurst et al., 2002; Enard et al., 2002; Pennisi 2002]. Deficiency studies in rodents [Sinclair and Crawford 1972; Benolken et al., 1973; Galli and Socini, 1983; Weisinger et al., 1999; Catalan et al., 2002], chickens [Budowski et al., 1987], primates [Fiennes et al., 1973; Neuringer et al., 1986], and visual and cognitive trials in human infants [Carlson and Werkman, 1996; Martinez and Vazquez, 1998; Birch et al., 2000] have indicated that both AA and DHA are essential for brain development and function. Moreover, the competition that exists between n–6/n–3 fatty acids applies to their balance being critical for brain development and structural integrity [Budowski and Crawford, 1985]. DHA is essential in vision, brain neurones and cell signalling.