Development and hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity.
Development and hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity.
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DOI：
10.1177/0885328214538866
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发表时间：
2014-10
影响因子：
2.9
通讯作者：
Bartlett RH
中科院分区：
文献类型：
--
作者：
Major TC;Handa H;Annich GM;Bartlett RH
血液相容性是体外生命支持（ECLS）医疗设备中包含的任何生物材料的目标。血液相容性的标志包括非血栓性、血小板保存和维持血小板功能。在过去的几十年里，血液/生物材料界面相容性的体外和体内测试已经被用于确定医用导管和设备中使用的生物材料是否需要全身抗凝以保证其生存能力。在过去的50年里，肝素系统抗凝一直是维持有效ECLS的金标准。然而，在不使用任何全身抗凝剂的情况下维持有效ECLS的生物材料仍然是难以捉摸的。在这篇综述中，体内4小时兔子血栓形成模型的发生将被描述，重点是可能不需要全身抗凝治疗的ECLS长寿生物材料。这些新型生物材料可以通过保持主要血液成分，血小板和单核细胞的近静息生理学来改善体外循环（ECC）血液相容性。兔ECC模型提供了生物材料与内在凝血因子、循环血小板和单核细胞相互作用的完整评估。血液/生物材料相互作用的全图表明，这种兔血栓形成模型可以为生物材料血液相容性测试提供标准化。
Hemocompatibility is the goal for any biomaterial contained in extracorporeal life supporting (ECLS) medical devices. The hallmarks for hemocompatibility include nonthrombogenicity, platelet preservation and maintained platelet function. Both in vitro and in vivo assays testing for compatibility of the blood/biomaterial interface have been used over the last several decades to ascertain if the biomaterial used in medical tubing and devices will require systemic anticoagulation for viability. Over the last 50 years systemic anticoagulation with heparin has been the gold standard in maintaining effective ECLS. However, the biomaterial that maintains effective ECLS without the use of any systemic anticoagulant has remained elusive. In this review, the in vivo 4-h rabbit thrombogenicity model genesis will be described with emphasis on biomaterials that may require no systemic anticoagulation for ECLS longevity. These novel biomaterials may improve extracorporeal circulation (ECC) hemocompatibility by preserving near resting physiology of the major blood components, the platelets and monocytes. The rabbit ECC model provides a complete assessment of biomaterial interactions with the intrinsic coagulation players, the circulating platelet and monocytes. This total picture of blood/biomaterial interaction suggests that this rabbit thrombogenicity model could provide a standardization for biomaterial hemocompatibility testing.
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影响因子：
3.1
作者：
Cho, Chi Hyun;Woo, Mi Kyung;Kim, Woo Joo
通讯作者：
Kim, Woo Joo
影响因子：
8.8
作者：
Chetty, Vani;Moodley, Dhayendre;Chuturgoon, Anil
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Chuturgoon, Anil
影响因子：
3.5
作者：
ASKEW, SC;BUTLER, AR;MEGSON, IL
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MEGSON, IL
影响因子：
11.4
作者：
Aszódi, A;Pfeifer, A;Fässler, R
通讯作者：
Fässler, R
影响因子：
7.3
作者：
Batchelor, MM;Reoma, SL;Meyerhoff, ME
通讯作者：
Meyerhoff, ME