TWO NEW ALKALOIDS FROM THE SEEDS OF CASSIA ALATA AND THEIR BIOACTIVITIES
TWO NEW ALKALOIDS FROM THE SEEDS OF CASSIA ALATA AND THEIR BIOACTIVITIES
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决明子中两种新生物碱及其生物活性
DOI：
10.3987/com-16-13511
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发表时间：
2016
期刊：
影响因子：
0.6
通讯作者：
Wang Jia-Qiang
中科院分区：
文献类型：
--
作者：
Yang Pei-Song;Zhang Wei;Shen Xiao-Feng;Wang Xin-Lin;Li Chao;Gong Xiao-Wei;Zheng Xu-Dong;Zhu Dong-Lai;Wang Jia-Qiang
两种新的生物碱，6-(羟甲基)-3,9-二甲基-7H-苯并[de]-喹啉-7-酮 (1) 和 6-(羟甲基)-8-甲氧基-3,9-二甲基-7H-苯并[de]-喹啉-7-酮 (2)，以及四种已知的生物碱 (3-6) 从 决明子的种子。它们的结构是通过 HRESIMS 和广泛的一维和二维核磁共振波谱研究确定的。测试了化合物1-6的抗烟草花叶病毒(TMV)活性，结果表明，化合物2具有较高的抗TMV活性，抑制率为38.5%。该比率高于阳性对照的比率。还测试了化合物1-6针对五种人类肿瘤细胞系（NB4、A549、SHSY5Y、PC3和MCF7）的细胞毒性。化合物1-6对一些测试的人肿瘤细胞系表现出弱抑制活性，IC50值在2.5-7.5μM范围内。
Two new alkaloids, 6-(hydroxymethyl)-3,9-dimethyl-7H-benzo[de]-quinolin-7-one (1) and 6-(hydroxymethyl)-8-methoxy-3,9-dimethyl-7H-benzo[de]-quinolin-7-one (2), together with four known alkaloids (3-6) were isolated from the seeds of Cassia alata. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-6 were tested for their anti-tobacco mosaic virus (TMV) activities, and the results showed that compound 2 exhibited high anti-TMV activity with inhibition rates of 38.5%. This rate is higher than that of the positive control. The cytotoxicities of compounds 1-6 against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) were also tested. Compounds 1-6 showed weak inhibitory activities against some tested human tumor cell lines with IC50 values in the range of 2.5-7.5 mu M.