Tea and cancer prevention: epidemiological studies.
Tea and cancer prevention: epidemiological studies.
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DOI：
10.1016/j.phrs.2011.03.002
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发表时间：
2011-08
影响因子：
9.3
通讯作者：
Butler LM
中科院分区：
文献类型：
--
作者：
Yuan JM;Sun C;Butler LM
实验研究一致表明茶提取物在多种模型系统中对肿瘤发生具有抑制活性。然而，流行病学研究在人类中产生了不确定的结果。进行了一项全面的审查，以评估当前有关茶叶消费和人类癌症风险的知识。一般来说，饮用红茶与降低癌症风险无关。在充分控制混杂因素后，大量摄入绿茶始终与降低上消化道癌症风险相关。有限的数据支持绿茶对肺癌和肝细胞癌的保护作用。尽管观察性研究不支持茶摄入对前列腺癌风险的有益作用，但 II 期临床试验已证明绿茶提取物对前列腺癌前病变的进展具有抑制作用。绿茶可能对绝经前妇女的乳腺癌发生和乳腺癌复发发挥有益作用。没有足够的证据支持茶摄入对结直肠癌、胰腺癌、尿路癌、神经胶质瘤、淋巴瘤和白血病的发展具有保护作用。未来需要利用暴露生物标志物和 III 期临床试验进行前瞻性观察研究，为假设的饮茶对人类癌症形成的有益影响提供明确的证据。
Experimental studies have consistently shown the inhibitory activities of tea extracts on tumorigenesis in multiple model systems. Epidemiologic studies, however, have produced inconclusive results in humans. A comprehensive review was conducted to assess the current knowledge on tea consumption and risk of cancers in humans. In general, consumption of black tea was not associated with lower risk of cancer. High intake of green tea was consistently associated with reduced risk of upper gastrointestinal tract cancers after sufficient control for confounders. Limited data support a protective effect of green tea on lung and hepatocellular carcinogenesis. Although observational studies do not support a beneficial role of tea intake on prostate cancer risk, phase II clinical trials have demonstrated an inhibitory effect of green tea extract against the progression of prostate pre-malignant lesions. Green tea may exert beneficial effects against mammary carcinogenesis in premenopausal women and recurrence of breast cancer. There is no sufficient evidence that supports a protective role of tea intake on the development of cancers of the colorectum, pancreas, urinary tract, glioma, lymphoma, and leukemia. Future prospective observational studies with biomarkers of exposure and phase III clinical trials are required to provide definitive evidence for the hypothesized beneficial effect of tea consumption on cancer formation in humans.