Cognitive Function in Children with Lupus Nephritis: A Cross-Sectional Comparison with Children with Other Glomerular Chronic Kidney Diseases
Cognitive Function in Children with Lupus Nephritis: A Cross-Sectional Comparison with Children with Other Glomerular Chronic Kidney Diseases
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DOI：
10.1016/j.jpeds.2017.06.044
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发表时间：
2017-10-01
影响因子：
5.1
通讯作者：
Hooper, Stephen R.
中科院分区：
文献类型：
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作者：
Knight, Andrea;Kogon, Amy J.;Hooper, Stephen R.
目的探讨狼疮性肾炎儿童认知功能障碍的影响因素。研究设计采用标准化测量方法对全国多中心慢性肾病(CKD)儿童队列进行横断面分析，以确定34例狼疮性肾炎(n=34)的基线神经精神功能和健康相关生活质量(HRQOL)，并与其他形式的肾小球CKD(n=171)的基线功能进行比较。我们通过倾向评分分析的Logistic模型使用逆概率加权来实现狼疮性肾炎儿童和其他肾小球原因的CKD儿童之间的平衡，调整了已知的混杂因素。我们使用线性回归模型来比较暴露组之间的神经认知结果，调整当前泼尼松的使用，测试当前强的松使用与狼疮性肾炎之间的交互作用，并测试认知功能与高质量生活质量之间的关联。
Objective To identify factors contributing to cognitive impairment in children with lupus nephritis.Study design A cross-sectional analysis of a large multicenter national cohort of children with chronic kidney disease (CKD) using standardized measures to determine baseline neuropsychiatric function and health-related quality of life (HRQoL) in children with lupus nephritis (n = 34), and to compare baseline function with that in children with other forms of glomerular CKD (gCKD; n = 171). We used inverse probability weighting via a logistic model for propensity score analysis to achieve balance between children with lupus nephritis and those with other glomerular causes of CKD, adjusting for known confounders. We used linear regression models to compare neurocognitive outcomes between exposure groups, adjusting for current prednisone use and testing for an interaction between current prednisone use and lupus nephritis, and to test for an association between cognitive function and HRQoL.Results Current prednisone use was independently associated with worse attention (P