Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating
Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating
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DOI：
10.1016/j.physbeh.2010.09.006
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发表时间：
2010-12-02
影响因子：
2.9
通讯作者：
Massi, Maurizio
中科院分区：
文献类型：
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作者：
Cifani, Carlo;Di B, Maria Vittoria Micioni;Massi, Maurizio
由于红景天具有调节应激反应的作用，本研究以雌性大鼠为实验动物，通过3次为期8天的限食/再喂，诱发高适口性食物（HPF）的BE（对于4天，66%的通常食物摄入，对于4天，食物随意）和在测试日的急性应激（第25天）在进入HPF前1h灌胃给予（3% rosavin 3 12% salidroside）或其有效成分。玫瑰提取物10 mg/kg显著降低和20 mg/kg消除BE发作R玫瑰提取物20 mg/kg也消除应激诱导的血清皮质酮水平的增加依赖性地减少或消除BE的时期，它是elicatedIn结论结果表明，它玫瑰提取物可能具有治疗性质，暴饮暴食相关的饮食失调和红景天苷是负责这种效果的有效原则（C）2010爱思唯尔公司版权所有
Stress is a key determinant of binge eating (BE) Since Rhodiola rosea is known to modulate stress responses its effect in a model of BE was investigatedBE for highly palatable food (HPF) was evoked in female rats by three 8-day cycles of food restriction/refeeding (for 4 days 66% of the usual chow intake for 4 days food ad libitum) and acute stress on the test day (day 25) R rosea dry extract (3% rosavin 3 12% salidroside) or its active principles were given by gavage 1 h before access to HPF Only rats exposed to both food restrictions and stress exhibited BE in the first 15-60 min after the stressful procedure R. rosea extract 10 mg/kg significantly reduced and 20 mg/kg abolished the BE episode R rosea extract 20 mg/kg abolished also stress-Induced increase in serum corticosterone levels The R rosea active principle salidroside but not rosavin at doses present in the extract dose-dependently reduced or abolished BE for the period in which it was elicitedIn conclusion results indicate that It rosea extracts may have therapeutic properties in bingeing-related eating disorders and that salidroside is the active principle responsible for this effect (C) 2010 Elsevier Inc All rights reserved