Prognostic significance of histological grade in clear-cell carcinoma of the ovary: a retrospective study of Korean Gynecologic Oncology Group
Prognostic significance of histological grade in clear-cell carcinoma of the ovary: a retrospective study of Korean Gynecologic Oncology Group
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DOI：
10.1093/annonc/mdn764
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发表时间：
2009-06-01
影响因子：
50.5
通讯作者：
Kang, S. -B.
中科院分区：
文献类型：
--
作者：
Ryu, S. -Y.;Park, S. -I.;Kang, S. -B.
背景资料：本研究旨在探讨卵巢透明细胞癌（CCC）患者的临床病理特征的预后意义。材料与方法：201例卵巢CCC患者在韩国妇科肿瘤组登记。韩国妇科病理学研究组使用通用分级系统集中审查了病理切片。结果：本组病例中，大多数患者早期诊断（I期61.3%），5年生存率为57%。早期疾病预后良好，晚期疾病预后差。多因素分析显示，疾病分期是唯一有意义的预后因素（P < 0.001）。然而，在逐步似然比检验中，普遍分级和残留肿瘤也显示出预后意义。紫杉醇为基础的和铂类为基础的联合化疗治疗的患者之间没有观察到生存差异。结论：阶段，残留肿瘤，和普遍的分级是卵巢CCC患者的重要预后因素。该分级系统可用于判断卵巢CCC的预后。还需要进一步的临床试验来寻找最佳的化疗方案。
Background: This study was to investigate the prognostic significance of clinicopathologic characteristics in patients with clear-cell carcinoma (CCC) of the ovary.Materials and methods: Two hundred and one patients with CCC of the ovary were registered in the Korean Gynecologic Oncology Group. The Korean Gynecologic Pathology Study Group reviewed the pathological slides centrally, using a universal grading system. The prognostic significances of clinicopathologic factors were evaluated by multivariate analysis.Results: Most of the patients were diagnosed at an early stage (stage I, 61.3%), and the overall 5-year survival rate was 57%. Early-stage disease showed a favorable prognosis, but advanced diseases showed poor prognosis. Stage of disease was the only significant prognostic factor on multivariate analysis (P < 0.001). However, universal grade and residual tumor also showed prognostic significance on the forward stepwise likelihood ratio test. There was no survival difference observed between patients treated with paclitaxel-based and those treated with platinum-based combination chemotherapy.Conclusions: The stage, residual tumor, and universal grade were significant prognostic factors in patients with CCC of the ovary. The universal grading system is applicable in determining prognosis of CCC of the ovary. Further clinical trials for optimal chemotherapy are in need.