SEX-HORMONE-RELATED EVENTS IN MIGRAINOUS FEMALES - A CLINICAL COMPARATIVE-STUDY BETWEEN MIGRAINE WITH AURA AND MIGRAINE WITHOUT AURA
SEX-HORMONE-RELATED EVENTS IN MIGRAINOUS FEMALES - A CLINICAL COMPARATIVE-STUDY BETWEEN MIGRAINE WITH AURA AND MIGRAINE WITHOUT AURA
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DOI：
10.1046/j.1468-2982.1995.015002140.x
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发表时间：
1995-04-01
期刊：
影响因子：
4.9
通讯作者：
SILVESTRINI, M
中科院分区：
文献类型：
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作者：
CUPINI, LM;MATTEIS, M;SILVESTRINI, M
在这项研究中，研究了激素相关事件与有先兆偏头痛 (MA) 和无先兆偏头痛 (MO) 之间的关系。受试者包括 268 名患有 MA（88 名）和 MO（180 名）的女性。收集了性激素相关事件与偏头痛之间关系的数据。 MO 患者在月经期间出现偏头痛的比例显着高于 MA 患者 (p < 0.03)。 MO 患者的月经性偏头痛明显比 MA 患者更常见 (p < 0.01)。 MA 患者在怀孕期间开始偏头痛的比例显着高于 MO 患者 (p < 0.01)。两组患者在初潮时、绝经后、产后期或口服避孕药早期周期中偏头痛的发作没有显着差异。此外，两组患者在怀孕、口服避孕药使用和更年期期间都表现出相似的偏头痛病程。八名同时患有先兆偏头痛和无先兆偏头痛的患者报告在服用口服避孕药的早期周期中首次出现先兆症状。这些发现表明性腺激素波动可能会影响两种类型的偏头痛。
In this study, the relationship between hormonal-related events and migraine with aura (MA) and without aura (MO) was investigated. Subjects included 268 women suffering from MA (88) and MO (180). Data were collected on the relationship between sex-hormone-related events and migraine. Migraine during menses was observed in a significantly higher percentage of MO than MA patients (p < 0.03). Menstrual migraine was significantly more common in MO than in MA patients (p < 0.01). Migraine began during pregnancy in a significantly higher percentage of MA than of MO patients (p < 0.01). No significant difference was observed between the two groups of patients regarding the onset of migraine at menarche, after menopause, in the postpartum period or during the early cycles of oral contraceptives. Also, both groups of patients showed a similar migraine course during pregnancy, oral contraceptive use and menopause. Eight patients with coexisting migraine with aura and migraine without aura attacks reported the appearance of the aura symptom for the first time in the early cycles of oral contraceptive intake. These findings suggest that gonadal hormone fluctuation may influence both types of migraine.