Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis.
Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis.
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DOI：
10.1371/journal.pone.0177023
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Wu Y;Ni J;Cai X;Lian F;Ma H;Xu L;Yang L
一些研究探讨了醛脱氢酶2家族（ALDH2） rs671多态性与原发性高血压（EH）之间的关系。然而，结果仍然不一致。本研究旨在阐明ALDH2 rs671多态性与EH易感性之间的关系。这项以人群为基础的病例对照研究收集了1494例汉族病例和1236例对照。采用固定或随机效应模型，采用等位基因对比、显性、隐性和共显性模型，进行荟萃分析，计算合并优势比和95%置信区间。EH病例与对照组在基因型（χ2 = 6.656， P<0.05）和等位基因（χ2 = 6.314， P<0.05）水平上差异均有统计学意义。另一项使用4204例病例和5435例对照的meta分析证实rs671与EH显著相关（P<0.00001）。我们的病例对照研究和荟萃分析结果显示，ALDH2 rs671多态性与EH易感性之间存在显著相关性。此外，性别细分分析的结果表明，ALDH2 rs671多态性与EH之间存在男性特异性关联。
Several studies have been conducted to examine the association between aldehyde dehydrogenase 2 family (ALDH2) rs671 polymorphism and essential hypertension (EH). However, the results remain inconsistent. This study aimed to clarify the association between ALDH2 rs671 polymorphism and EH susceptibility. One thousand and ninety-four cases and 1236 controls who were ethnic Han Chinese were collected for this population-based case-control study. A meta-analysis was performed to calculate the pooled odds ratio and 95% confidence interval, using allele contrast, dominant, recessive, and co-dominant models using fixed or random-effect models. Significant differences were observed between EH cases and controls at the level of both genotype (χ2 = 6.656, P<0.05) and alleles (χ2 = 6.314, P<0.05). An additional meta-analysis using 4204 cases and 5435 controls established that rs671 was significantly associated with EH (P<0.00001). The results of our case-control study and meta-analysis showed that there is a significant association between ALDH2 rs671 polymorphism and EH susceptibility. In addition, the results of the breakdown analysis by gender suggest a male-specific association between the ALDH2 rs671 polymorphism and EH.