The Cellular Stress Gene Response in Brain
The Cellular Stress Gene Response in Brain
复制标题
大脑中的细胞应激基因反应
DOI：
10.1007/978-3-642-58259-2_11
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发表时间：
1999
影响因子：
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通讯作者：
F. Sharp
中科院分区：
文献类型：
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作者：
I. Brown;F. Sharp
利用在组织培养中生长的哺乳动物细胞，在热休克反应的分子生物学和热休克蛋白（hsps）在修复和保护机制中的作用方面取得了相当大的进展（Morimoto 1993; Morimoto et al. 1994;另见第10章）。3，这卷）。最近，越来越多的工作已经进行了完整的体温调节动物。如本文所示，热休克反应是生理相关的，因为热休克基因在哺乳动物神经系统中在应激处理如发热样温度、局灶性脑缺血和蛛网膜下腔出血后被打开。大脑是一个复杂的结构，由许多类型的细胞组成。如将变得明显的，神经元和神经胶质细胞类型在hsps的组成性表达中表现出差异，并且在体内激活热休克反应的脑细胞的类型取决于应激的性质和严重性。
Considerable advances in the molecular biology of the heat shock response and the role of heat shock proteins (hsps) in repair and protective mechanisms have been made using mammalian cells grown in tissue culture (Morimoto 1993; Morimoto et al. 1994; see also Chap. 3, this volume). Recently, an increasing amount of work has been carried out on intact thermoregulating animals. As will be shown in this article, the heat shock response is physiologi cally relevant since heat shock genes are turned on in the mammalian nervous system following stress treatments such as fever-like temperature, focal cerebral ischemia and subarachnoid hemorrhage. The brain is a complex structure composed of many cell types. As will become apparent, neuronal and glial cell types exhibit differences in constitutive expression of hsps and the type of brain cell that activates the heat shock response in vivo depends on the nature and the severity of the stress.
N.Saito：“G_2(q) 上的一些字符和和高斯和，将出现在 Tokyo J.Math 中。”
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