Do biochemical markers have a role in osteoarthritis diagnosis and treatment?
Do biochemical markers have a role in osteoarthritis diagnosis and treatment?
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DOI：
10.1016/j.berh.2005.09.001
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发表时间：
2006-02-01
影响因子：
5.2
通讯作者：
Kraus, VB
中科院分区：
文献类型：
--
作者：
Kraus, VB
可以在队列研究和临床试验中使用生物标志物来增加我们对疾病的了解，阐明疾病机制，并增强对骨关节炎疾病状态的临床印象。是否可以有意义地利用生物标志物来表征个体患者的疾病状态仍有待观察。本综述描述了与生物标志物用于研究和临床实践相关的主要概念以及影响生物标志物浓度的因素，以探讨生物标志物在骨关节炎诊断、预后和治疗中的潜在作用。
It is possible to use biomarkers in cohort studies and in clinical trials to increase our understanding of disease, to elucidate disease mechanisms, and to bolster a clinical impression of the disease state of osteoarthritis. Whether it will be possible to utilize biomarkers meaningfully to characterize the disease state in an individual patient remains to be seen. Major concepts related to the use of biomarkers for research and clinical practice, and factors influencing biomarker concentrations, are described in this review in order to address the potential role of biomarkers in osteoarthritis diagnosis, prognosis, and treatment.