Epidemiology and Outcomes of Fever Burden Among Patients With Acute Ischemic Stroke
Epidemiology and Outcomes of Fever Burden Among Patients With Acute Ischemic Stroke
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DOI：
10.1161/strokeaha.111.621425
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发表时间：
2011-12-01
期刊：
影响因子：
8.3
通讯作者：
Bravata, Dawn M.
中科院分区：
文献类型：
--
作者：
Phipps, Michael S.;Desai, Rani A.;Bravata, Dawn M.
背景和目的-虽然缺血性卒中后发热是常见的，并已与不良的患者预后，很少有人知道哪些方面的发热（如，频率，严重程度，或持续时间）是最相关的outcome. Methods-我们使用的数据从一个回顾性队列的急性缺血性卒中患者谁被承认的5家医院之一（1998-2003年）。发热事件被定义为温度>= 100.0华氏度（37.8摄氏度）的时期。发热负担定义为最高温度（T（max））减去100.0华氏度，乘以发热天数。发热负担（以度日为单位）分为低（0.1-2.0）、中（2.1-4.0）或高（>= 4.0）。Logistic回归分析用于评估调整后的任何发热事件和发热负担与院内死亡率或出院到安宁疗护的综合结局的相关性。结果在1361例卒中患者中，483例（35.5%）有≥ 1次发热事件。在发热患者中，中位T（max）为100.9华氏度（范围，100.0-106.6华氏度），87%的患者
Background and Purpose-Although fever following ischemic stroke is common and has been associated with poor patient outcomes, little is known about which aspects of fever (eg, frequency, severity, or duration) are most associated with outcomes.Methods-We used data from a retrospective cohort of acute ischemic stroke patients who were admitted to 1 of 5 hospitals (1998-2003). A fever event was defined as a period with a temperature >= 100.0 degrees F (37.8 degrees C). Fever burden was defined as the maximum temperature (T(max)) minus 100.0 degrees F, multiplied by the number of days with a fever. Fever burden (in degree-days) was categorized as low (0.1-2.0), medium (2.1-4.0), or high (>= 4.0). Logistic regression was used to evaluate the adjusted association of any fever episode and fever burden with the combined outcome of in-hospital mortality or discharge to hospice.Results-Among 1361 stroke patients, 483 patients (35.5%) had >= 1 fever event. Among febrile patients, the median T(max) was 100.9 degrees F (range, 100.0-106.6 degrees F), 87% had