Predictive value of (18) F-FDG PET/CT and serum tumor markers for tumor mutational burden in patients with non-small cell lung cancer.
Predictive value of (18) F-FDG PET/CT and serum tumor markers for tumor mutational burden in patients with non-small cell lung cancer.
复制标题
作者：
目的探讨非小细胞肺癌(NSCLC)患者正电子发射断层扫描(PET/CT)摄取18F-脱氧葡萄糖(FDG)代谢参数(MPS)、血清肿瘤标志物(STM)和肿瘤突变负荷(TMB)之间的关系。在这项回顾性研究中，我们招募了129名非小细胞肺癌患者(男性78例，女性51例)，他们在2018年3月至2022年9月期间接受了基线TMB和STM测试以及18F-FDG PET/CT扫描。将患者分为高Tmb组(Tmb≥10突变/Mb；n = 27[20.9%])和非高Tmb组(Tmb≥10突变/Mb；n = 102[79.1%])。采用二元Logistic回归分析确定TMB-HIGH的独立预测因素。进行单变量和多变量线性回归分析，以确定对数尺度上TMB水平的独立预测因素。对腺癌、伴有表皮生长因子受体阳性的腺癌、伴有表皮生长因子受体−的腺癌和鳞癌进行亚组分析。对于ADC，TMB高转移组的所有MPS(SULak、SULmax、SULean、MTV和TLG)均显著高于非TMB高转移组；吸烟者(OR[OR] = 27.08，p = 0.018)、EGFR+(OR = 0.03，p = 0.033)、KRAS+(OR = 7.98，p = 0.083)、高CEA值(OR = 33.56，p = 0.029)、高CA125(OR = 13.68，p = 0.030)是TMB-HIGH的独立预测因素；然而，没有观察到显著的相关性与鳞癌。MPS和STM可以预测ADC患者的TMB水平，可作为TMB的潜在替代品，具有更高的价值和易于实施的非侵入性方法指导免疫治疗。
To investigate the correlations between metabolic parameters (MPs) of 18F‐fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT), serum tumor markers (STMs), and tumor mutational burden (TMB) in patients with non‐small cell lung cancer (NSCLC). In this retrospective study, we enrolled 129 patients with NSCLC (males, 78; females, 51) who underwent baseline TMB and STM tests and 18F‐FDG PET/CT scans before treatment between March 2018 and September 2022. Patients were categorized into TMB‐high (TMB ≥10 mutations/Mb; n = 27 [20.9%]) and non‐TMB‐high (TMB <10 mutations/Mb; n = 102 [79.1%]) groups. Binary logistic regression analyses were performed to determine independent predictors of TMB‐high. Univariate and multivariate linear regression analyses were performed to determine independent predictors of TMB level on a log scale. Subgroup analyses for adenocarcinoma (ADC), ADC with EGFR+, ADC with EGFR−, and squamous cell carcinoma (SCC) were performed. For ADC, all MPs (SULpeak, SULmax, SULmean, MTV, and TLG) were significantly higher in the TMB‐high group than the non‐TMB‐high group; smoker (odds ratio [OR] = 27.08, p = 0.018), EGFR+ (OR = 0.03, p = 0.033), KRAS+ (OR = 7.98, p = 0.083), high CEA (OR = 33.56, p = 0.029), and high CA125 (OR = 13.68, p = 0.030) were independent predictors of TMB‐high; and all MPs showed significant positive linear correlations with TMB on a log scale, with SULpeak as an independent predictor. However, no significant correlation was observed for SCC. MPs and STMs can predict the TMB level for patients with ADC, and may serve as potential substitutes for TMB with increased value and easy implementation in guiding immunotherapy through noninvasive methods.
登录
查看更多内容
DOI：
10.1158/1078-0432.ccr-16-3133
发表时间：
2017-08-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Kato S;Goodman A;Walavalkar V;Barkauskas DA;Sharabi A;Kurzrock R
通讯作者：
Kurzrock R
DOI：
10.1158/1078-0432.ccr-15-3101
发表时间：
2016-09-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Gainor JF;Shaw AT;Sequist LV;Fu X;Azzoli CG;Piotrowska Z;Huynh TG;Zhao L;Fulton L;Schultz KR;Howe E;Farago AF;Sullivan RJ;Stone JR;Digumarthy S;Moran T;Hata AN;Yagi Y;Yeap BY;Engelman JA;Mino-Kenudson M
通讯作者：
Mino-Kenudson M
影响因子：
5.7
作者：
Nishimura Y;Tomita Y;Yuno A;Yoshitake Y;Shinohara M
通讯作者：
Shinohara M
DOI：
10.1056/nejmoa1801946
发表时间：
2018-05-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hellmann MD;Ciuleanu TE;Pluzanski A;Lee JS;Otterson GA;Audigier-Valette C;Minenza E;Linardou H;Burgers S;Salman P;Borghaei H;Ramalingam SS;Brahmer J;Reck M;O'Byrne KJ;Geese WJ;Green G;Chang H;Szustakowski J;Bhagavatheeswaran P;Healey D;Fu Y;Nathan F;Paz-Ares L
通讯作者：
Paz-Ares L
影响因子：
4.7
作者：
Crivellaro, Cinzia;Signorelli, Mauro;Messa, Cristina
通讯作者：
Messa, Cristina