Predicting age at menopause from serum antimullerian hormone concentration
Predicting age at menopause from serum antimullerian hormone concentration
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DOI：
10.1097/gme.0b013e318205e2ac
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发表时间：
2011-07-01
影响因子：
2.7
通讯作者：
Azizi, Fereidoun
中科院分区：
文献类型：
--
作者：
Tehrani, Fahimeh Ramezani;Shakeri, Nezhat;Azizi, Fereidoun
目的：我们旨在利用血清抗苗勒氏管激素 (AMH) 浓度来估计绝经年龄。方法：我们从德黑兰脂质和血糖研究队列的 1,265 名符合条件的女性中随机选择了 266 名研究参与者。我们大约每隔 3 年测量 3 次 AMH 水平。在平均 6 年的随访中，我们的参与者中有 63 人出现了更年期。我们利用随访开始时的血清 AMH 水平建立了加速失败时间模型，以估计绝经年龄。使用 Cox-Snell 残差和 Bland-Altman 图测试模型的拟合优度。结果：我们根据不同血清 AMH 浓度水平估算了 20 至 49 岁女性的绝经年龄。对于那些达到更年期的人来说，事件发生前大约 6 年的血清 AMH 浓度可以相当准确地估计绝经年龄。 Bland-Altman 图显示预测值和观测值之间具有可接受的一致性。结论：血清 AMH 浓度可以合理预测个体女性的绝经年龄。
Objective: We aimed to estimate age at menopause using serum antimullerian hormone (AMH) concentration.Methods: We randomly selected 266 study participants from a pool of 1,265 eligible women in the Tehran Lipid and Glucose Study cohort. We measured AMH levels three times at about 3-year intervals. There were 63 occurrences of menopause in our participants over an average of 6-year follow-up. We built an accelerated failure time model using serum AMH level at the start of follow-up to estimate age at menopause. The goodness of fit for the model was tested using Cox-Snell residuals and the Bland-Altman plot.Results: We estimated ages at menopause for different levels of serum AMH concentration among women aged 20 to 49 years. For those who reached menopause, serum AMH concentrations about 6 years before the event provided fairly accurate estimates of the age at menopause. The Bland-Altman plot showed an acceptable agreement between predicted and observed values.Conclusions: Serum AMH concentrations can reasonably forecast the age at menopause for individual women.