Increasing incidence of multiple sclerosis among women in Buenos Aires: a 22 year health maintenance organization based study
Increasing incidence of multiple sclerosis among women in Buenos Aires: a 22 year health maintenance organization based study
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DOI：
10.1007/s10072-016-2637-3
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发表时间：
2016-10-01
影响因子：
3.3
通讯作者：
Rojas, J. I.
中科院分区：
文献类型：
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作者：
Cristiano, E.;Patrucco, L.;Rojas, J. I.
多发性硬化症 (MS) 的研究表明疾病患病率和发病率有增加的趋势，尤其是女性多发性硬化症的发病率不成比例地增加。本研究的目的是评估阿根廷布宜诺斯艾利斯一家健康维护组织 22 年来多发性硬化症的发病率，并确定男女发病率的比率。该人群由 1992 年 1 月至 2013 年 12 月期间附属于医院的 HMO 的所有成员组成。对每个人贡献的危险时间进行跟踪。明确诊断为多发性硬化症的病例也被纳入其中。发病率密度以 95% 置信区间计算，并在女性和男性之间进行比较。 165,456 名受试者接受了总计 1,488,575 人年的随访，其中 42 人罹患 MS。发病密度为 3/100,000 人年（95% CI 2.1-3.5/100,000 人年）。在此期间 (1992-2013)，女性发病率从 1/100,000 (95% CI 0.8-1.6) 上升至 4.9/100,000 (95% CI 4.1-5.4) (p < 0.001)，而男性发病率为 1.4/100,000 (95% CI) 1-1.7) 至 1.8 (1.3-2.1) (p = 0.16)。研究期间女性的发病密度显着增加，但男性则没有。这是拉丁美洲地区首次报道这一现象。
Studies in multiple sclerosis (MS) suggest a trend of increasing disease prevalence and incidence, and especially, a disproportional increase in the incidence of multiple sclerosis in women. The objective of this study was to evaluate the incidence of MS over 22 years and to determine the ratio in incidence of men to women in a health maintenance organization from Buenos Aires, Argentina. The population was made up of all members of a hospital-based HMO affiliated between January 1992 and December 2013. Each person was followed contributing time at risk. Cases with definite diagnosis of MS were included. Incidence density was calculated with 95 % confidence intervals and compared between women and men. 165,456 subjects were followed for a total of 1,488,575 person-years, of whom 42 developed MS. Incidence density was 3/100,000 person-years (95 % CI 2.1-3.5/100,000 person-years). During this period (1992-2013), the incidence rate in women increased from 1/100,000 (95 % CI 0.8-1.6) to 4.9/100,000 (95 % CI 4.1-5.4) (p < 0.001), while in men the incidence ranged from 1.4/100,000 (95 % CI 1-1.7) to 1.8 (1.3-2.1) (p = 0.16). Incidence density during the study period increased significantly in women but not in men. This is the first report of this phenomenon in Latin America region.