Corneal latency and transmission of herpes simplex virus-1.

Corneal latency and transmission of herpes simplex virus-1.
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角膜潜伏和单纯疱疹病毒1的传播。

DOI:
10.2217/fvl.10.74
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发表时间:
2011-01
期刊:
影响因子:
3.1
通讯作者:
Shukla D
Shukla D
中科院分区:
医学4区
文献类型:
--
作者:
Farooq AV;Shukla D

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单纯疱疹病毒(HSV)-1通过角膜移植传播的报道很少。据信,这些病例要么是由于病毒从三叉神经节传播到角膜,要么是由于供体角膜本身潜伏的HSV-1。对角膜组织中病毒长期存在的研究试图确定是否存在真正的非神经元潜伏期的证据,尽管在其定义上存在问题。最近的研究为神经元潜伏期提供了新的见解,而角膜中类似的HSV-1基因调控可能与角膜潜伏期的病理生理有关,并可能成为移植受体的潜在风险。这一问题引发了人们对眼库的担忧,目前眼库用于筛查其他传染性病原体,但不包括1型单纯疱疹病毒。在此,我们回顾了有关角膜潜伏期和HSV-1传播的文献。
The transmission of herpes simplex virus (HSV)-1 by corneal transplantation has rarely been reported. It is believed that these cases have resulted either from reactivated virus traveling from the trigeminal ganglion to the cornea or from latent HSV-1 in the donor cornea itself. Studies of long-term viral presence in corneal tissue have sought to determine whether there is evidence of true non-neuronal latency, although there are problems in its definition. Recent studies provide new insights into neuronal latency, while similar HSV-1 gene regulation in the cornea may implicate corneal latency in pathophysiology and as a potential risk for transplant recipients. This issue has led to concerns over eye banking, which currently screens for other infectious agents but not HSV-1. Here we review the literature regarding corneal latency and the transmission of HSV-1.
DOI: 10.1056/nejm199807303390503
发表时间: 1998-07-30
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