ACUTE CEREBRAL-ISCHEMIA - CONCURRENT CHANGES IN CEREBRAL BLOOD-FLOW, ENERGY METABOLITES, PH, AND LACTATE MEASURED WITH HYDROGEN CLEARANCE AND P-31 AND H-1 NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY .2. CHANGES DURING ISCHEMIA
ACUTE CEREBRAL-ISCHEMIA - CONCURRENT CHANGES IN CEREBRAL BLOOD-FLOW, ENERGY METABOLITES, PH, AND LACTATE MEASURED WITH HYDROGEN CLEARANCE AND P-31 AND H-1 NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY .2. CHANGES DURING ISCHEMIA
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DOI：
10.1038/jcbfm.1987.82
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发表时间：
1987-08-01
影响因子：
6.3
通讯作者：
RUSSELL, RWR
中科院分区：
文献类型：
--
作者：
CROCKARD, HA;GADIAN, DG;RUSSELL, RWR
在氟烷麻醉下，用氢清除法测定了沙土鼠双侧大脑半球的脑血流量。这与用1H和31P核磁共振波谱在同一动物中测量的局部pH、组织乳酸和磷能量代谢物的变化有关。我们证明了与能量衰竭相关的代谢变化的阈值流量值与先前报道的电气故障和组织水分积累的值相似，但高于与细胞外钾稳态破坏相关的值。
CBF has been measured with the hydrogen clearance technique in the two cerebral hemispheres of the gerbil under halothane anaesthesia. This has been correlated with changes in local pH, tissue lactate, and phosphorus energy metabolites measured in the same animals with 1H and 31P nuclear magnetic resonance spectroscopy. We demonstrate a threshold flow value for the metabolic changes associated with energy failure at a level similar to the values previously reported for electrical failure and tissue water accumulation, but higher than that associated with breakdown of extracellular potassium homeostasis.