Genotype C of hepatitis B virus can be classified into at least two subgroups
Genotype C of hepatitis B virus can be classified into at least two subgroups
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DOI：
10.1099/vir.0.19633-0
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发表时间：
2004-02-01
影响因子：
3.8
通讯作者：
Abe, K
中科院分区：
文献类型：
--
作者：
Huy, TTT;Ushijima, H;Abe, K
对来自5个亚洲国家的56个前s1 /前s2基因和10个全长HBV基因型C分离株进行了乙型肝炎病毒（HBV）的基因组鉴定。对前s1 /前s2基因的系统发育分析显示，基因型C中存在两大类群：一组来自东南亚，包括越南、缅甸和泰国（命名为HBV/C1），另一组来自远东，包括日本、韩国和中国（命名为HBV/C2）。基于32株HBV基因型C株（其中22株来自数据库条目）全长序列的系统发育分析证实了这一发现。来自日本南端冲绳岛的两个分离株形成了一个不同的分支。大S蛋白（51、54、60、62和73个氨基酸）和P蛋白（231、233、236、248、252和304个氨基酸）的氨基酸序列发生了特异性变化。我们的研究结果表明，基因型C型HBV可分为至少两个亚群。
A genomic characterization of hepatitis B virus (HBV) was done for 56 pre-S1/pre-S2 genes and 10 full-length HBV genotype C isolates from five Asian countries. Phylogenetic analysis of the pre-S1 /pre-S2 genes revealed two major groups within genotype C: one for isolates from southeast Asia including Vietnam, Myanmar and Thailand (named HBV/C1) and the other for isolates from Far East Asia including Japan, Korea and China (named HBV/C2). This finding was confirmed by phylogenetic analysis based on the full-length sequence of 32 HBV genotype C isolates, including 22 from database entries. Two isolates from Okinawa, the island off the southern end of Japan, formed a different branch. Specific amino acid sequence changes were identified in the large S protein (amino acids 51, 54, 60, 62 and 73) and P protein (amino acids 231, 233, 236, 248, 252 and 304). Our results indicate that genotype C of HBV can be classified into at least two subgroups.