Bcl-2 family gene products in cerebral ischemia and traumatic brain injury
Bcl-2 family gene products in cerebral ischemia and traumatic brain injury
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DOI：
10.1089/neu.2000.17.831
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发表时间：
2000-10-01
影响因子：
4.2
通讯作者：
Clark, RSB
中科院分区：
文献类型：
--
作者：
Graham, SH;Chen, J;Clark, RSB
原癌基因bcl-2在神经元程序性细胞死亡的调控中起着关键作用。本文综述了bcl-2家族基因调控程序性细胞死亡的机制及其在脑缺血和脑外伤中的作用。脑缺血和脑外伤后，bcl-2家族的几个成员表达发生改变，提示bcl-2家族基因可能在决定损伤神经元的命运中起作用。此外，使用转基因方法、病毒载体或反义寡核苷酸改变bcl-2家族基因的表达改变损伤后的神经元细胞死亡和神经学结果。这些数据表明bcl-2家族基因产物的活性参与确定缺血和创伤中的细胞和神经学结果，模拟bcl-2家族基因产物的死亡抑制效应或抑制其死亡促进效应的策略可能改善缺血和创伤后的预后。
The proto-oncogene bcl-2 plays a key role in regulating programmed cell death in neurons, The present review discusses the mechanisms by which bcl-2 family genes regulate programmed cell death, and their role in controlling cell death in cerebral ischemia and traumatic brain, Expression of several bcl-2 family members is altered in brain tissues after ischemia and trauma, suggesting that bcl-2 family genes could play a role in determining the fate of injured neurons. Furthermore, alteration of expression of bcl-2 family genes using transgenic approaches, viral vectors, or anti-sense oligonucleotides modifies neuronal cell death and neurological outcome after injury, These data suggest that the activity of bcl-2 family gene products participates in determining cellular and neurologic outcomes in ischemia and trauma, Strategies that either mimic the death-suppressor effects or inhibit the death-promoter effects of bcl-2 family gene products may improve outcome after ischemia and trauma.