Differential use of the βL subunit of the type I interferon (IFN) receptor determines signaling specificity for IFNα2 and IFNβ
Differential use of the βL subunit of the type I interferon (IFN) receptor determines signaling specificity for IFNα2 and IFNβ
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DOI：
10.1074/jbc.273.6.3144
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发表时间：
1998-02-06
影响因子：
4.8
通讯作者：
Colamonici, OR
中科院分区：
文献类型：
--
作者：
Domanski, P;Nadeau, OW;Colamonici, OR
具有共同受体亚基的细胞因子的信号传导特异性通过额外的精氨酸特异性受体组分的存在来实现。在I型干扰素（IFN）家族中，IFN α、IFN β和IFN ω的所有14种亚型都与I型IFN-R的相同α和β（L）亚基结合，但它们之间存在信号传导和生物学效应的差异。我们的数据表明IFN α 2和IFN β利用β（L）亚基的不同区域进行信号传导。因此，与其它细胞因子系统相反，I型IFN系统中的信号多样性可以通过利用相同受体亚基的不同区域在相同受体复合物内实现。
The signaling specificity for cytokines that have common receptor subunits is achieved by the presence of additional cytokine-specific receptor components. In the type I interferon (IFN) family, all 14 subtypes of IFN alpha, IFN beta, and IFN omega bind to the same alpha and beta(L), subunits of the type I IFN-R, yet differences in signaling and biological effects exist among them. Our data demonstrate that IFN alpha 2 and IFN beta utilize different regions of the beta(L), subunit for signaling, Thus, in contrast to other cytokine systems, signal diversity in the type I IFN system can be accomplished within the same receptor complex by utilizing different regions of the same receptor subunits.