Protection from high-fat-diet-induced impaired glucose tolerance in female Sprague-Dawley rats
Protection from high-fat-diet-induced impaired glucose tolerance in female Sprague-Dawley rats
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保护雌性斯普拉格道利大鼠免受高脂肪饮食引起的糖耐量受损
DOI：
10.1080/09513590902770107
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发表时间：
2009-07-01
影响因子：
2
通讯作者：
Gan, Lixia
中科院分区：
文献类型：
--
作者：
Lu, Zhongyan;Wang, Zhe;Gan, Lixia
在这项研究中，我们研究了高脂肪（HF）饮食与标准食物（SC）饮食对遗传正常的Sprague-Dawley大鼠葡萄糖代谢的长期影响。由于饲料给药时间为14个月，因此大鼠几乎终生暴露于饲料。结果表明：（1）SC或HF喂养14个月后，雄性和雌性大鼠空腹血糖均低于5.1mmol/l，（2）SC组和HF组雄性大鼠腹腔内葡萄糖耐量试验后2h血糖浓度（2hPG）显著高于雌性大鼠;（3）HF组大鼠肝脏甘油三酯含量显著高于SC组，组织学染色显示HF组雌雄大鼠均出现严重的肝脏脂肪变性;（4）HF组男性空腹血胰岛素浓度显著高于女性，稳态模型胰岛素抵抗评分也显著高于女性;（5）HF喂养的雌性大鼠对葡萄糖刺激的胰岛素分泌能力显著高于雄性大鼠。综上所述，这些数据表明，HF饮食在大鼠中产生的葡萄糖耐受不良显示出性别差异，并且雌性大鼠在HF条件下免受葡萄糖耐量受损的发展。
In this study, we examined the long-term influence of a high-fat (HF) diet compared with a standard chow (SC) diet on glucose metabolism in genetically normal Sprague-Dawley rats. As the diet was given for a period of 14 months it represents almost a life-long exposure of the rats to the diet. Results showed that (1) after exposure to 14 months of SC or HF feeding, the fasting glucose levels were below 5.1 mmol/l in both genders; (2) the 2 h plasma glucose concentration (2 h PG) of male rats after an intraperitoneal glucose tolerance test for the SC groups and for the HF groups was significantly higher than for females; (3) the liver triglycerides content was significantly enhanced by HF feeding as compared with SC-feeding, and histological staining showed that both genders of the HF group developed severe liver steatosis; (4) the fasting insulin concentration in blood of HF-fed males was significantly higher than that of females and homeostasis model assessment of insulin resistance was also significantly higher; (5) the insulin secretion capabilities in response to glucose stimulation were significantly higher in HF-fed female rats than that of males. Taken together, these data indicate that glucose intolerance produced by a HF diet in rats shows a gender difference, and females are protected against development of impaired glucose tolerance under HF condition.