Widespread Vestibular Activation of the Rodent Cortex
Widespread Vestibular Activation of the Rodent Cortex
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DOI：
10.1523/jneurosci.1869-14.2015
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发表时间：
2015-04-15
影响因子：
5.3
通讯作者：
Margrie, Troy W.
中科院分区：
文献类型：
--
作者：
Rancz, Ede A.;Moya, Javier;Margrie, Troy W.
我们对空间导航的神经机制的理解大多来自啮齿动物的长期记录，其中头部方向，位置和网格细胞都被描述过。然而，尽管提出了自我参考信息的重要性，这些内部表征的空间，他们的一致性与前庭信号仍然不清楚。在这里，我们已经进行了全脑功能映射使用功能磁共振成像和电生理方法直接确定的空间范围，强度和时间过程中的前庭信号通过大鼠前脑。我们发现分布在整个丘脑，边缘系统，特别是初级感觉皮质区的活动，除了已知的头部方向的途径。我们还观察到额叶区域的激活，包括边缘下皮层和扣带皮层，表明前庭信息在功能多样的皮层区域的整合。因此，这些全脑活动图表明前庭信号对多模态感觉运动整合的自我中心框架的广泛贡献，以支持运动规划，执行，空间导航和对重力惯性变化的自主反应。
Much of our understanding of the neuronal mechanisms of spatial navigation is derived from chronic recordings in rodents in which head-direction, place, and grid cells have all been described. However, despite the proposed importance of self-reference information to these internal representations of space, their congruence with vestibular signaling remains unclear. Here we have undertaken brain-wide functional mapping using both fMRI and electrophysiological methods to directly determine the spatial extent, strength, and time course of vestibular signaling across the rat forebrain. We find distributed activity throughout thalamic, limbic, and particularly primary sensory cortical areas in addition to known head-direction pathways. We also observe activation of frontal regions, including infralimbic and cingulate cortices, indicating integration of vestibular information throughout functionally diverse cortical regions. These whole-brain activity maps therefore suggest a widespread contribution of vestibular signaling to a self-centered framework for multimodal sensorimotor integration in support of movement planning, execution, spatial navigation, and autonomic responses to gravito-inertial changes.