EFFECT OF DIFFERENTIAL REARING ON SYNAPSES AND SOMA SIZE IN RAT MEDIAL AMYGDALOID NUCLEUS
EFFECT OF DIFFERENTIAL REARING ON SYNAPSES AND SOMA SIZE IN RAT MEDIAL AMYGDALOID NUCLEUS
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DOI：
10.1002/syn.890130107
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发表时间：
1993-01-01
期刊：
影响因子：
2.3
通讯作者：
MORI, Y
中科院分区：
文献类型：
--
作者：
ICHIKAWA, M;MATSUOKA, M;MORI, Y
研究了不同饲养方式对成年大鼠杏仁内侧核(MAN)突触形态和神经元大小的影响。-40日龄雄性大鼠按三种饲养方式之一饲养：单独饲养(隔离条件，IC)；每笼饲养四只雄性(单性饲养，UC)；或每笼饲养两只雄性和两只雌性(社交条件，SC)。2个月后，对动物进行电子显微镜和光镜检查。尽管单位体积的突触数目在MAN中没有显著差异，但UC和SC中以突触后密度不连续为特征的穿孔(P)突触数量显著多于IC。UC和SC的P突触接触带长度也比IC长，而非穿孔突触的长度仅SC长。SC组的胞体面积也大于IC组。这些结果表明，暴露在不同的饲养条件下，信息素环境可以有很大的不同，可以诱导成年大鼠突触和神经元的显著形态变化。
The effects of differential rearing on synaptic morphology and neuronal size were examined in the medial amygdaloid nucleus (MAN) of adult rats.-Forty-day-old male rats were housed in one of three ways: individually (isolated condition, IC); with four males per cage (unisexual condition, UC); or with two males and two females per cage (social condition, SC). After 2 months, the animals were prepared for electron and light microscopy. Although there was no statistically significant difference in number of synapses per unit volume in MAN, the number of perforated (P) synapses, which are characterized by discontinuities in the postsynaptic density, were significantly greater in the UC and the SC than in the IC. The length of synaptic contact zone of P synapses was also longer in both the UC and the SC compared with the IC, whereas the length of nonperforated synapses was longer only in the SC. Soma area was also larger in the SC compared with the IC. These results demonstrate that exposure to different rearing conditions, in which the pheromonal environment can be substantially different, can induce striking morphological changes in both synapses and neurons in the MAN of adult rats.