The role of apolipoprotein E in the nervous system.
The role of apolipoprotein E in the nervous system.
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DOI：
10.1097/00041433-199404000-00007
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发表时间：
1994-04
影响因子：
4.4
通讯作者：
K. Weisgraber;A. Roses;W. Strittmatter
中科院分区：
文献类型：
--
作者：
K. Weisgraber;A. Roses;W. Strittmatter
人类载脂蛋白E是血浆脂蛋白代谢的重要组成部分，近年来被认为与阿尔茨海默病有关。在三个常见的载脂蛋白E等位基因中，epsilon 4已成为主要的危险因素。这篇综述总结了导致这一结论的数据，并基于最近的生化研究讨论了载脂蛋白E参与的可能机制。
Human apolipoprotein (apo)E, an important component of plasma lipoprotein metabolism, was recently linked to Alzheimer's disease. Of the three common apoE alleles, epsilon 4 has emerged as a major risk factor. This review summarizes the data leading to this conclusion and discusses possible mechanisms for apoE involvement based on recent biochemical studies.