Neisseria gonorrhoeae Becomes Susceptible to Polymyxin B and Colistin in the Presence of PBT2
Neisseria gonorrhoeae Becomes Susceptible to Polymyxin B and Colistin in the Presence of PBT2
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DOI：
10.1021/acsinfecdis.9b00307
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发表时间：
2020-01-01
影响因子：
5.3
通讯作者：
Jennings, Michael P.
中科院分区：
文献类型：
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作者：
Jen, Freda E. -C.;Everest-Dass, Arun V.;Jennings, Michael P.
淋病奈瑟菌引起性传播疾病淋病，每年全球发病率为1.06亿例。目前还没有预防这种疾病的疫苗，而且多药耐药(MDR)菌株的出现使淋病奈瑟菌对公共卫生构成直接威胁。在这里，我们展示了一个离子载体，PBT2，可以逆转淋球菌对多粘菌素B和粘菌素的内在耐药性。这些抗生素与PBT2联合应用可能是治疗耐多药淋球菌感染的有效途径。
Neisseria gonorrhoeae (N. gonorrhoeae) causes the sexually transmitted disease gonorrhea, which has a global incidence of 106 million cases per year. No vaccine is available to prevent the disease, and the emergence of multidrug resistant (MDR) strains makes N. gonorrhoeae an immediate public health threat. Here, we show that an ionophore, PBT2, can reverse the intrinsic resistance of N. gonorrhoeae to polymyxin B and colistin. These antibiotics administered in combination with PBT2 may be an effective path to treat MDR gonococcal infections.